About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rimklbem1Matak
endonuclease-mediated mutation 1, Masaoki Takano
MGI:6693818
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rimklbem1Matak/Rimklbem1Matak C57BL/6J-Rimklbem1Matak MGI:6693828


Genotype
MGI:6693828
hm1
Allelic
Composition		 Rimklbem1Matak/Rimklbem1Matak
Genetic
Background		 C57BL/6J-Rimklbem1Matak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rimklbem1Matak mutation (0 available); any Rimklb mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
asthenozoospermia ( J:303850 )
• attenuation of sperm motility
abnormal seminiferous tubule morphology ( J:303850 )
• incidence of seminiferous tubules with large vacuoles is increased at 8 and 13 weeks of age
decreased testis weight ( J:303850 )
• testes weights are reduced at 13 and 20 weeks of age
abnormal spermatogenesis ( J:303850 )
• males exhibit incomplete spermatogenesis, showing large vacuoles in seminiferous tubules at 8 and 13 weeks of age
abnormal sperm head morphology ( J:303850 )
• mice show an increase in the percentage of sperm head abnormalities, showing small and abnormally shaped heads
male infertility ( J:303850 )
• while wild-type females show plugs after mating with mutant males, they do not become pregnant and do not birth pups
• however, no change in testosterone level is seen in males
impaired fertilization ( J:303850 )
• in vitro fertilization using spermatozoa from 3-month-old mice shows almost no fertility with intact oocytes (1.7% fertilized eggs with mutant spermatozoa vs. 53.8% fertilized eggs with wild-type spermatozoa)
• however, spermatozoa is able to bind to the zona pellucida in in vitro fertilization experiments and some eggs show 2 pronuclei

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:303850 )
• incidence of seminiferous tubules with large vacuoles is increased at 8 and 13 weeks of age
decreased testis weight ( J:303850 )
• testes weights are reduced at 13 and 20 weeks of age

cellular
abnormal sperm head morphology ( J:303850 )
• mice show an increase in the percentage of sperm head abnormalities, showing small and abnormally shaped heads
asthenozoospermia ( J:303850 )
• attenuation of sperm motility




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory