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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rimklbem1Matak
endonuclease-mediated mutation 1, Masaoki Takano
MGI:6693818
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rimklbem1Matak/Rimklbem1Matak C57BL/6J-Rimklbem1Matak MGI:6693828


Genotype
MGI:6693828
hm1
Allelic
Composition		 Rimklbem1Matak/Rimklbem1Matak
Genetic
Background		 C57BL/6J-Rimklbem1Matak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rimklbem1Matak mutation (0 available); any Rimklb mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
asthenozoospermia ( J:303850 )
• attenuation of sperm motility
abnormal seminiferous tubule morphology ( J:303850 )
• incidence of seminiferous tubules with large vacuoles is increased at 8 and 13 weeks of age
decreased testis weight ( J:303850 )
• testes weights are reduced at 13 and 20 weeks of age
abnormal spermatogenesis ( J:303850 )
• males exhibit incomplete spermatogenesis, showing large vacuoles in seminiferous tubules at 8 and 13 weeks of age
abnormal sperm head morphology ( J:303850 )
• mice show an increase in the percentage of sperm head abnormalities, showing small and abnormally shaped heads
male infertility ( J:303850 )
• while wild-type females show plugs after mating with mutant males, they do not become pregnant and do not birth pups
• however, no change in testosterone level is seen in males
impaired fertilization ( J:303850 )
• in vitro fertilization using spermatozoa from 3-month-old mice shows almost no fertility with intact oocytes (1.7% fertilized eggs with mutant spermatozoa vs. 53.8% fertilized eggs with wild-type spermatozoa)
• however, spermatozoa is able to bind to the zona pellucida in in vitro fertilization experiments and some eggs show 2 pronuclei

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:303850 )
• incidence of seminiferous tubules with large vacuoles is increased at 8 and 13 weeks of age
decreased testis weight ( J:303850 )
• testes weights are reduced at 13 and 20 weeks of age

cellular
abnormal sperm head morphology ( J:303850 )
• mice show an increase in the percentage of sperm head abnormalities, showing small and abnormally shaped heads
asthenozoospermia ( J:303850 )
• attenuation of sperm motility




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/24/2024
MGI 6.24 		The Jackson Laboratory