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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hspa13tm1.1Smoc
targeted mutation 1.1, Shanghai Model Organisms Center
MGI:6694146
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hspa13tm1.1Smoc/Hspa13tm1.1Smoc
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * 129S * C57BL/6 MGI:6694201
cn2
 		Faslpr/Faslpr
Hspa13tm1.1Smoc/Hspa13tm1.1Smoc
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * 129S * C57BL/6 * MRL/Mp MGI:6694199


Genotype
MGI:6694201
cn1
Allelic
Composition		 Hspa13tm1.1Smoc/Hspa13tm1.1Smoc
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * 129S * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Hspa13tm1.1Smoc mutation (0 available); any Hspa13 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased plasma cell number ( J:303927 )
• reduced TACI+CD138+B220-CD19int early cells and TACI+CD138+B220-CD19- mature cells in the spleen, lymph nodes and bone marrow
• reduced LPS-induced TACI+CD138+B220-CD19int early plasma cells and TACI+CD138+B220-CD19- mature plasma cells
• decreased sheep red blood cell induced IgG1-, Ig2b-, IgG2c-, and IgG3 expressing plasma cells
abnormal plasmablast number ( J:303927 )
• decreased TACI+CD138+B220intCD19int cells
• decreased plasmablasts in LPS-treated mice
• decreased sheep red blood cell induced IgG1-, Ig2b-, IgG2c-, and IgG3 expressing plasmablasts
abnormal humoral immune response ( J:303927 )
• mice treated with NP-Ficoll and NP-KLH exhibit reduced NP-specific IgM, IgG, IgG1, IgG2b, IgG2c, IgG3, IgA, and IgE antibodies
decreased IgA level ( J:303927 )
• at baseline
decreased IgE level ( J:303927 )
• at baseline
decreased IgG level ( J:303927 )
• at baseline or mice treated with sheep red blood cells
decreased IgG1 level ( J:303927 )
• at baseline and in LPS- or sheep red blood cell-treated mice
decreased IgG2b level ( J:303927 )
• at baseline and in LPS- or sheep red blood cell-treated mice
decreased IgG2c level ( J:303927 )
• at baseline and in LPS- or sheep red blood cell-treated mice
decreased IgG3 level ( J:303927 )
• at baseline and in LPS- or sheep red blood cell-treated mice
decreased IgM level ( J:303927 )
• at baseline and in LPS- or sheep red blood cell-treated mice
decreased autoantibody level ( J:303927 )
• in mice treated with pristane compared with similarly treated control mice

renal/urinary system
increased urine protein level ( J:303927 )
• in mice treated with pristane that is not as high as in control mice

homeostasis/metabolism
increased urine protein level ( J:303927 )
• in mice treated with pristane that is not as high as in control mice
decreased susceptibility to injury ( J:303927 )
• mice treated with hydrocarbon oil 2, 6, 10, 14-tetramethylpentadecane (TMPD or pristane) to induce systemic lupus erythematosus exhibit reduced increase in autoantibody levels and proteinuria compared with control mice

hematopoietic system
decreased plasma cell number ( J:303927 )
• reduced TACI+CD138+B220-CD19int early cells and TACI+CD138+B220-CD19- mature cells in the spleen, lymph nodes and bone marrow
• reduced LPS-induced TACI+CD138+B220-CD19int early plasma cells and TACI+CD138+B220-CD19- mature plasma cells
• decreased sheep red blood cell induced IgG1-, Ig2b-, IgG2c-, and IgG3 expressing plasma cells
abnormal plasmablast number ( J:303927 )
• decreased TACI+CD138+B220intCD19int cells
• decreased plasmablasts in LPS-treated mice
• decreased sheep red blood cell induced IgG1-, Ig2b-, IgG2c-, and IgG3 expressing plasmablasts
decreased IgA level ( J:303927 )
• at baseline
decreased IgE level ( J:303927 )
• at baseline
decreased IgG level ( J:303927 )
• at baseline or mice treated with sheep red blood cells
decreased IgG1 level ( J:303927 )
• at baseline and in LPS- or sheep red blood cell-treated mice
decreased IgG2b level ( J:303927 )
• at baseline and in LPS- or sheep red blood cell-treated mice
decreased IgG2c level ( J:303927 )
• at baseline and in LPS- or sheep red blood cell-treated mice
decreased IgG3 level ( J:303927 )
• at baseline and in LPS- or sheep red blood cell-treated mice
decreased IgM level ( J:303927 )
• at baseline and in LPS- or sheep red blood cell-treated mice




Genotype
MGI:6694199
cn2
Allelic
Composition		 Faslpr/Faslpr
Hspa13tm1.1Smoc/Hspa13tm1.1Smoc
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * 129S * C57BL/6 * MRL/Mp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Faslpr mutation (39 available); any Fas mutation (82 available)
Hspa13tm1.1Smoc mutation (0 available); any Hspa13 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to systemic lupus erythematosus ( J:303927 )
• mice exhibit reduced increase in autoantibody levels and proteinuria levels compared with control mice
decreased autoantibody level ( J:303927 )
• compared with Faslpr homozygotes

renal/urinary system
increased urine protein level ( J:303927 )
• not as severe as in Faslpr homozygotes

homeostasis/metabolism
increased urine protein level ( J:303927 )
• not as severe as in Faslpr homozygotes




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory