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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sprnem1Jvt
endonuclease-mediated mutation 1, JL Vilotte
MGI:6694148
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sprnem1Jvt/Sprnem1Jvt FVB/NJ-Sprnem1Jvt MGI:6694866


Genotype
MGI:6694866
hm1
Allelic
Composition		 Sprnem1Jvt/Sprnem1Jvt
Genetic
Background		 FVB/NJ-Sprnem1Jvt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sprnem1Jvt mutation (0 available); any Sprn mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and placentation, incomplete penetrance ( J:289583 )
• some mice die prior shortly after implantation to E7.5

integument
abnormal mammary gland development ( J:289583 )
• some enlarged primary canals in virgin and lactating mammary glands
• less and only primary side branching in gestating and lactating tissues
abnormal mammary gland physiology ( J:289583 )
• fewer proliferating cells and more disperse apoptotic cells compared with wild-type mice
abnormal lactation ( J:289583 )
• pups from nursing dams exhibit reduced weight regardless of genotype
• however, milk protein, iron, zinc, and copper concentrations are normal
abnormal milk composition ( J:289583 )
• reduced milk fat gobule volume, enriched in free cholesterol

growth/size/body
decreased birth weight ( J:289583 )
• despite normal fetal weight and placental tissue weight
postnatal growth retardation ( J:289583 )

endocrine/exocrine glands
abnormal mammary gland development ( J:289583 )
• some enlarged primary canals in virgin and lactating mammary glands
• less and only primary side branching in gestating and lactating tissues
abnormal mammary gland physiology ( J:289583 )
• fewer proliferating cells and more disperse apoptotic cells compared with wild-type mice
abnormal lactation ( J:289583 )
• pups from nursing dams exhibit reduced weight regardless of genotype
• however, milk protein, iron, zinc, and copper concentrations are normal
abnormal milk composition ( J:289583 )
• reduced milk fat gobule volume, enriched in free cholesterol

cellular
maternal effect ( J:289583 )
• pups from nursing dams exhibit reduced weight regardless of genotype




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory