Analysis Tools
behavior/neurological
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• in the reciprocal social interaction test, mice spend less time interacting with strangers
• in the 3-chamber test, mice show impaired novelty preference, with less obvious preference for stranger 2 versus stranger 1, however no effect on sociability is seen
• zinc supplementation ameliorates the social deficits in the reciprocal social interaction test, with mice spending significantly longer interacting with the unfamiliar mouse
• treatment with D-cycloserine, a co-agonist of NMDAR, improved social interaction in the reciprocal social interaction test to wild-type levels
• however, mice behave normally in the open field and elevated plus maze
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• isolated pups exhibit shorter call duration, reduced calling frequency, and longer latency to have the first call at P6 but not P8
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homeostasis/metabolism
nervous system
