Phenotypes associated with this allele

• Allele Symbol: Vps4b^em1.1Nju
• Allele Name: endonuclease-mediated mutation 1.1, Model Animal Research Center of Nanjing University
• Allele ID: MGI:6694861
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vps4b^em1.1Nju/Vps4b^em1.1Nju	B6(Cg)-Vps4b^em1.1Nju	MGI:6694863
ht2	Vps4b^em1.1Nju/Vps4b^+	B6(Cg)-Vps4b^em1.1Nju	MGI:6694864

Genotype
MGI:6694863

hm1

• Allelic Composition: Vps4b^em1.1Nju/Vps4b^em1.1Nju
• Genetic Background: B6(Cg)-Vps4b^em1.1Nju

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:304329 )

• no live-born homozygotes are obtained and embryos are detected at E9.5 but are completely resorbed at E10.5 or beyond, indicating that embryos implant but die at the postimplantation stage

• E8.5 embryos undergo autolysis while E10.5 embryos undergo complete autolysis

embryo

placenta hemorrhage ( J:304329 )

• hemorrhaged placenta is seen in resorbed E12.5 embryos

embryonic growth retardation ( J:304329 )

• embryos exhibit severe growth retardation

abnormal placenta morphology ( J:304329 )

• placenta is frequently darker in color, suggesting a defect in vascularization and/or poor blood supply

• E12.5 embryos placenta is grossly disorganized, has disordered and incomplete vascularization, lacks trophoblast giant cells, has fuzzy boundaries among the spongy cell layer, labyrinth, and chorionic lamina, and has reduced numbers of nucleated cells

abnormal placenta vasculature ( J:304329 )

• E12.5 embryos placenta has disordered and incomplete vascularization

absent trophoblast giant cells ( J:304329 )

• E12.5 embryos placenta lacks trophoblast giant cells

small placenta ( J:304329 )

growth/size/body

embryonic growth retardation ( J:304329 )

• embryos exhibit severe growth retardation

cardiovascular system

abnormal placenta vasculature ( J:304329 )

• E12.5 embryos placenta has disordered and incomplete vascularization

hemorrhage ( J:304329 )

• embryos show obvious spot bleeding at E8.5-E10.5

placenta hemorrhage ( J:304329 )

• hemorrhaged placenta is seen in resorbed E12.5 embryos

Genotype
MGI:6694864

ht2

• Allelic Composition: Vps4b^em1.1Nju/Vps4b⁺
• Genetic Background: B6(Cg)-Vps4b^em1.1Nju

normal phenotype

no abnormal phenotype detected ( J:304329 )

• mice show no abnormalities in weight, diet or fertility