Phenotypes associated with this allele

• Allele Symbol: Tmem175^em2Dren
• Allele Name: endonuclease-mediated mutation 2, Dejian Ren
• Allele ID: MGI:6695106
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmem175^em2Dren/Tmem175^em2Dren	C57BL/6J-Tmem175^em2Dren	MGI:6695126
ht2	Tmem175^em2Dren/Tmem175^+	C57BL/6J-Tmem175^em2Dren	MGI:6695127

Genotype
MGI:6695126

hm1

• Allelic Composition: Tmem175^em2Dren/Tmem175^em2Dren
• Genetic Background: C57BL/6J-Tmem175^em2Dren

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased cellular sensitivity to hydrogen peroxide ( J:304120 )

• neurons show less damage in response to insult with reactive oxygen species such as H202

decreased susceptibility to neuronal excitotoxicity ( J:304120 )

• neurons show less damage in response to insults such as the neurotoxin MPTP or nutrient removal

abnormal lysosome physiology ( J:304120 )

• lysosomal K+ current in starved neurons is intact even after 6 hours and requires 9 hours to be eliminated compared to wild-type neurons which show elimination of the K+ current after a 3 hours starvation

homeostasis/metabolism

decreased susceptibility to neuronal excitotoxicity ( J:304120 )

• neurons show less damage in response to insults such as the neurotoxin MPTP or nutrient removal

nervous system

decreased susceptibility to neuronal excitotoxicity ( J:304120 )

• neurons show less damage in response to insults such as the neurotoxin MPTP or nutrient removal

Genotype
MGI:6695127

ht2

• Allelic Composition: Tmem175^em2Dren/Tmem175⁺
• Genetic Background: C57BL/6J-Tmem175^em2Dren

cellular

abnormal lysosome physiology ( J:304120 )

• lysosomal K+ current in neurons is about 30% smaller than that of wild-type mice under B27-replete condition but is larger than that of wild-type mice after a 3-hour starvation and requires 6 hours to be eliminated