About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myh3tm1.1Sajm
targeted mutation 1.1, Sam J Mathew
MGI:6695298
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Myh3tm1.2Sajm/Myh3tm1.1Sajm
Pax7tm1(cre)Mrc/Pax7+ 		involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J MGI:6695908
cn2
 		Myh3tm1.2Sajm/Myh3tm1.1Sajm
Pax3tm1(cre)Joe/Pax3+ 		involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6J MGI:6695907


Genotype
MGI:6695908
cn1
Allelic
Composition		 Myh3tm1.2Sajm/Myh3tm1.1Sajm
Pax7tm1(cre)Mrc/Pax7+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh3tm1.1Sajm mutation (0 available); any Myh3 mutation (74 available)
Myh3tm1.2Sajm mutation (0 available); any Myh3 mutation (74 available)
Pax7tm1(cre)Mrc mutation (2 available); any Pax7 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle precursor cell morphology ( J:287755 )
• reduction in myogenic precursor marker Pax7 peptide level and 50% reduction in Pax7+ myogenic precursor cells in E16.5 embryos
• significantly reduced levels of committed myoblast markers MyoD and myogenin peptide levels and 60% reduction in MyoD+ myoblasts in E16.5 embryos
• 7x increased MyHC-slow peptide levels in E16.5 embryos

cellular
cellular phenotype ( J:287755 )
N
• normal apoptosis in E16.5 embryos




Genotype
MGI:6695907
cn2
Allelic
Composition		 Myh3tm1.2Sajm/Myh3tm1.1Sajm
Pax3tm1(cre)Joe/Pax3+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh3tm1.1Sajm mutation (0 available); any Myh3 mutation (74 available)
Myh3tm1.2Sajm mutation (0 available); any Myh3 mutation (74 available)
Pax3tm1(cre)Joe mutation (1 available); any Pax3 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle precursor cell morphology ( J:287755 )
• 50% reduction in myogenic precursor marker Pax7 peptide level in E13.5 embryos
• significantly increased levels of committed myoblast markers MyoD and myogenin peptide levels in E13.5 embryos




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory