Phenotypes associated with this allele

• Allele Symbol: Rab44^em1Rbrc
• Allele Name: endonuclease-mediated mutation 1, RIKEN BioResource Center
• Allele ID: MGI:6695900
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rab44^em1Rbrc/Rab44^em1Rbrc	Not Specified	MGI:6695901

Genotype
MGI:6695901

hm1

• Allelic Composition: Rab44^em1Rbrc/Rab44^em1Rbrc
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal mast cell physiology ( J:304506 )

• bone marrow-derived mast cells stimulated with DNP-human serum albumin exhibit reduced beta-hexosaminidase secretion compared with wild-type mice

• however, beta-hexosaminidase secretion stimulated by PMA is normal

increased susceptibility to type I hypersensitivity reaction ( J:304506 )

• in mice treated with anti-DNP IgE and challenged with DNP-HAS or mice treated with ovalbumin exhibit a greater reduction in rectal body temperature compared with wild-type mice

homeostasis/metabolism

decreased susceptibility to induced hypothermia ( J:304506 )

• to a greater extent than normal in mice treated with anti-DNP IgE and challenged with DNP-HAS or mice treated with ovalbumin

decreased circulating histamine level ( J:304506 )

• in mice treated with anti-DNP IgE and challenged with DNP-HSA

hematopoietic system

abnormal mast cell physiology ( J:304506 )

• bone marrow-derived mast cells stimulated with DNP-human serum albumin exhibit reduced beta-hexosaminidase secretion compared with wild-type mice

• however, beta-hexosaminidase secretion stimulated by PMA is normal