Phenotypes associated with this allele

• Allele Symbol: Wdfy2^tm1.1Wgz
• Allele Name: targeted mutation 1.1, Wei-Guo Zhu
• Allele ID: MGI:6695933
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wdfy2^tm1.1Wgz/Wdfy2^tm1.1Wgz	involves: C57BL/6J	MGI:6695934

Genotype
MGI:6695934

hm1

• Allelic Composition: Wdfy2^tm1.1Wgz/Wdfy2^tm1.1Wgz
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased liver weight ( J:296933 )

♂ • livers are heavier at 8 months of age

homeostasis/metabolism

increased circulating insulin level ( J:296933 )

♂ • mice exhibit higher serum insulin levels under fasting conditions at 3 and 8 months of age

increased circulating cholesterol level ( J:296933 )

♂ • mild increase in serum cholesterol levels at 3 months and a significant increase at 8 months of age

increased circulating triglyceride level ( J:296933 )

♂ • increase in serum triglyceride levels at 8 months, but not 3 months, of age

impaired glucose tolerance ( J:296933 )

♂ • mice show impaired glucose reduction in the glucose tolerance test

decreased liver glycogen level ( J:296933 )

♂ • decrease in glycogen deposits in the liver at 3 months of age

increased hepatic glucose production ( J:296933 )

♂ • pyruvate tolerance tests in 3-month-old mice show an increase in hepatic glucose output

insulin resistance ( J:296933 )

♂ • mice show reduced insulin sensitivity in insulin tolerance testing

increased liver cholesterol level ( J:296933 )

♂ • 8-month-old liver shows increased cholesterol content

increased liver triglyceride level ( J:296933 )

♂ • 8-month-old liver shows increased triglyceride content

liver/biliary system

increased liver weight ( J:296933 )

♂ • livers are heavier at 8 months of age

decreased liver glycogen level ( J:296933 )

♂ • decrease in glycogen deposits in the liver at 3 months of age

increased liver cholesterol level ( J:296933 )

♂ • 8-month-old liver shows increased cholesterol content

increased liver triglyceride level ( J:296933 )

♂ • 8-month-old liver shows increased triglyceride content

hepatic steatosis ( J:296933 )

♂ • 8-month-old liver shows mild but obvious hepatic steatosis