Phenotypes associated with this allele

• Allele Symbol: Ccdc8^tm1.2Yxi
• Allele Name: targeted mutation 1.2, Yue Xiong
• Allele ID: MGI:6695964
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccdc8^tm1.2Yxi/Ccdc8^tm1.2Yxi	B6.129P2(Cg)-Ccdc8^tm1.2Yxi	MGI:6712648

Genotype
MGI:6712648

hm1

• Allelic Composition: Ccdc8^tm1.2Yxi/Ccdc8^tm1.2Yxi
• Genetic Background: B6.129P2(Cg)-Ccdc8^tm1.2Yxi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:303998 )

• although homozygous mutant mice are identified up to E18.5, no viable births are obtained from heterozygous intercrosses

growth/size/body

decreased fetal size ( J:303998 )

• at E18.5, fetuses are significantly smaller than heterozygous or wild-type controls

decreased fetal weight ( J:303998 )

• at E18.5

prenatal growth retardation ( J:303998 )

• intrauterine growth restriction

embryo

abnormal placental labyrinth vasculature morphology ( J:303998 )

• at E12.5, maternal vessel area (%) is significantly decreased whereas fetal vessel area (%) is unaffected

abnormal placenta intervillous maternal lacunae morphology ( J:303998 )

• branching of the maternal blood sinus in the labyrinth area is significantly reduced

thin placenta labyrinth ( J:303998 )

• placenta is thinner in the labyrinth area

abnormal placenta development ( J:303998 )

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:303998 )

• at E12.5, maternal vessel area (%) is significantly decreased whereas fetal vessel area (%) is unaffected

cellular

cellular phenotype ( J:303998 )

N • mouse embryonic fibroblasts (MEFs) exhibit normal proliferation potential relative to wild-type MEFs

decreased fibroblast cell migration ( J:303998 )

• MEFs exhibit decreased cell migration and cell invasion in Boyden chamber transwell assays