Phenotypes associated with this allele

• Allele Symbol: Vps13b^em1Yosl
• Allele Name: endonuclease-mediated mutation 1, Yong-Seok Lee
• Allele ID: MGI:6695987
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vps13b^em1Yosl/Vps13b^em1Yosl	C57BL/6N-Vps13b^em1Yosl	MGI:6695991

Genotype
MGI:6695991

hm1

• Allelic Composition: Vps13b^em1Yosl/Vps13b^em1Yosl
• Genetic Background: C57BL/6N-Vps13b^em1Yosl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:285279 )

N • normal time spent in central and peripheral areas in open field test

N • normal anxiety behavior in zero-maze and light-dark box tests

N • normal working memory in Y-maze test

N • normal swimming speeds in Morris water maze test

N • normal freezing behavior in contextual fear conditioning test

N • normal social preference and social novelty behavior in three-chamber test

impaired spatial learning ( J:285279 )

• longer latency to find hidden platform during training sessions and no increase in time spent in target quadrant during probe sessions in Morris water maze test

• normal performance in Morris water maze test when flag placed on hidden platform

impaired coordination ( J:285279 )

• shorter latency to fall in accelerating rotarod test

decreased locomotor activity ( J:285279 )

• less distance traveled under dim light in open field test