mortality/aging
• while most die prior to E6.5, a rare occurrence of 2 embryos surviving to the perinatal stage is seen but no weanling pups are detected
|
• early-stage embryonic lethality prior to E6.5, with no detectable homozygous weanling pups with the exception of a very rare occurrence of embryos surviving to a perinatal stage of development (E18.5)
|