Phenotypes associated with this allele

• Allele Symbol: Tomm7^em1Yihc
• Allele Name: endonuclease-mediated mutation 1, Yi-Han Chen
• Allele ID: MGI:6695994
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tomm7^em1Yihc/Tomm7^em1Yihc	Not Specified	MGI:6695996

Genotype
MGI:6695996

hm1

• Allelic Composition: Tomm7^em1Yihc/Tomm7^em1Yihc
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal vasculogenesis ( J:285108 )

• sparse vascular tree (fewer, and less branching, capillaries) inside cerebral parenchyma at age P12

• overall normal cerebrovascular architecture and major cerebral vessels

• normal cardiac vasculature

growth/size/body

postnatal growth retardation ( J:285108 )

• much smaller at age P12

• normal size at birth

• normal lung, heart, small intestine, stomach, and spleen histology, apart from smaller size

slow postnatal weight gain ( J:285108 )

• much smaller at age P12

• normal weight at birth

• normal lung, heart, small intestine, stomach, and spleen histology, apart from smaller size

mortality/aging

preweaning lethality, complete penetrance ( J:285108 )

• mice die before age P21

cellular

oxidative stress ( J:285108 )

• elevated ROS production in isolated brain endothelial cells

nervous system

decreased brain size ( J:285108 )

• at age P12

embryo

embryo phenotype ( J:285108 )

N • mice born at normal Mendelian ratio