Phenotypes associated with this allele

• Allele Symbol: Pi4kb^tm1.1Tbal
• Allele Name: targeted mutation 1, Tamas Balla
• Allele ID: MGI:6696050
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pi4kb^tm1.1Tbal/Pi4kb^tm1.1Tbal Tg(Mpz-cre)26Mes/0	involves: 129S6/SvEvTac * C57BL/6 * FVB	MGI:6696059

Genotype
MGI:6696059

cn1

• Allelic Composition: Pi4kb^tm1.1Tbal/Pi4kb^tm1.1Tbal; Tg(Mpz-cre)26Mes/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal Schwann cell morphology ( J:297534 )

• reduction to almost complete lack of caveolae, missing or severely underdeveloped Schwann cell microvilli, and disorganized Golgi

decreased myelin sheath amount ( J:297534 )

• in small diameter axons

abnormal node of Ranvier morphology ( J:297534 )

• missing or severely underdeveloped Schwann cell microvilli allowing for axon herniation

• disintegration of basal lamina around the Remak bundles

• disorganization of the Node of Ranvier

abnormal sciatic nerve morphology ( J:297534 )

• more nuclei and deduced total lipid content with reduced sphingomyelin and phosphatidylethanolamine

decreased nerve conduction velocity ( J:297534 )

behavior/neurological

limb grasping ( J:297534 )

impaired coordination ( J:297534 )

• small impairment

abnormal gait ( J:297534 )

• noticeable at 3 weeks after birth

spasticity ( J:297534 )

• in hindlimb