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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zar1lem1Hyfn
endonuclease-mediated mutation 1, Heng-Yu Fan
MGI:6696064
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zar1lem1Hyfn/Zar1lem1Hyfn involves: C57BL/6 * ICR MGI:6696071
cx2
 		Zar1em1Hyfn/Zar1em1Hyfn
Zar1lem1Hyfn/Zar1lem1Hyfn 		involves: C57BL/6 * ICR MGI:6696073


Genotype
MGI:6696071
hm1
Allelic
Composition		 Zar1lem1Hyfn/Zar1lem1Hyfn
Genetic
Background		 involves: C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zar1lem1Hyfn mutation (0 available); any Zar1l mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:282460 )
N
• female mice exhibit normal fertility
abnormal female meiosis ( J:282460 )
• slightly slower germinal vesicle breakdown and slower first polar body release than in wild-type mice
impaired polar body extrusion ( J:282460 )
• slower first polar body release than in wild-type mice

cellular
abnormal female meiosis ( J:282460 )
• slightly slower germinal vesicle breakdown and slower first polar body release than in wild-type mice
impaired polar body extrusion ( J:282460 )
• slower first polar body release than in wild-type mice




Genotype
MGI:6696073
cx2
Allelic
Composition		 Zar1em1Hyfn/Zar1em1Hyfn
Zar1lem1Hyfn/Zar1lem1Hyfn
Genetic
Background		 involves: C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zar1em1Hyfn mutation (0 available); any Zar1 mutation (17 available)
Zar1lem1Hyfn mutation (0 available); any Zar1l mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal female meiosis ( J:282460 )
• slower germinal vesicle breakdown and first polar body release than in wild-type mice
abnormal female meiosis I arrest ( J:282460 )
• some oocytes fail to release the polar body and arrest at metaphase I
• even occytes that release the first polar body arrest in cytokinesis
impaired polar body extrusion ( J:282460 )
• slower first polar body release than in wild-type mice

cellular
aneuploidy ( J:282460 )
• in telophase I-arrested oocytes
abnormal female meiosis ( J:282460 )
• slower germinal vesicle breakdown and first polar body release than in wild-type mice
abnormal female meiosis I arrest ( J:282460 )
• some oocytes fail to release the polar body and arrest at metaphase I
• even occytes that release the first polar body arrest in cytokinesis
impaired polar body extrusion ( J:282460 )
• slower first polar body release than in wild-type mice
maternal effect ( J:282460 )
• nearly all embryos from females arrest at 1-cell stage with none developed beyond the 2-cell stage
• impaired maternal 3UTR activation, mRNA translation, and accumulation during oocyte development




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory