Phenotypes associated with this allele

• Allele Symbol: Ifnl3^em1Mtba
• Allele Name: endonuclease-mediated mutation 1, Megan T Baldridge
• Allele ID: MGI:6696076
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ifnl3^em1Mtba/Ifnl3^em1Mtba	involves: C57BL/6	MGI:6710974

Genotype
MGI:6710974

hm1

• Allelic Composition: Ifnl3^em1Mtba/Ifnl3^em1Mtba
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal circulating interferon level ( J:287260 )

• mice do not produce IFN-lambda after poly(I-C) induction

increased susceptibility to viral infection ( J:287260 )

• mice infected with the CR6 strain of murine norovirus show higher CR6 shedding in the stool at day 7 postinfection (dpi) than wild-type mice, and have higher numbers of CR6 genome copies in the colon, indicating a failure to control persistent norovirus replication

• mice show infection with a chimeric virus CR6^NS1-CW3, in which the CR6 nonstructural protein 1 (NS1) is replaced with the NS1 of acute murine norovirus strain CW3, showing viral replication which is not seen in wild-type mice

increased susceptibility to Riboviria infection ( J:287260 )

• mice inoculated perorally with reovirus strain type 1 Lang (T1L) , show elevated levels of reovirus titers in the stool, indicating increased levels of virus shedding, and increased viral loads in jejunal and ileal tissues compared to wild-type mice

increased susceptibility to Orthomyxoviridae infection ( J:287260 )

• mice inoculated intranasally with mouse-adapted influenza A virus PR8 show more weight loss than wild-type mice and elevated levels of lung PR8 viral loads at 3 dpi, however they recover from weigh loss by day 14 as in wild-type mice

homeostasis/metabolism

abnormal circulating interferon level ( J:287260 )

• mice do not produce IFN-lambda after poly(I-C) induction