Phenotypes associated with this allele

• Allele Symbol: Igh^tm3(IGH)Vlcg
• Allele Name: targeted mutation 3, Velocigene
• Allele ID: MGI:6696097
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh^tm3(IGH)Vlcg/Igh^tm3(IGH)Vlcg	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:6696142

Genotype
MGI:6696142

hm1

• Allelic Composition: Igh^tm3(IGH)Vlcg/Igh^tm3(IGH)Vlcg
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:277644 )

N • female mice exhibit normal fertility

N • male mice exhibit normal mating behavior and reproductive tissue morphology with normal sperm counts and motility

impaired sperm migration in female genital tract ( J:277644 )

♂ • severely limited sperm passage from the uterus to the oviduct due to reduced sperm to sperm adhesion

decreased litter size ( J:277644 )

♂ • 4 males only produce 2 litters totaling 4 pups in 6 months

reduced male fertility ( J:277644 )

♂ • severely reduced with 4 males only producing 2 litters totaling 4 pups in 6 months

impaired fertilization ( J:277644 )

♂ • small reduction in sperm binding to cumulus-intact oocytes

♂ • impaired binding to the zona pellucida

cellular

impaired sperm migration in female genital tract ( J:277644 )

♂ • severely limited sperm passage from the uterus to the oviduct due to reduced sperm to sperm adhesion