Phenotypes associated with this allele

• Allele Symbol: Flot2^em1Xidw
• Allele Name: endonuclease-mediated mutation 1, Xiaodong Wang
• Allele ID: MGI:6696115
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Flot1^em1Xidw/Flot1^em1Xidw Flot2^em1Xidw/Flot2^em1Xidw	FVB-Flot1^em1Xidw Flot2^em1Xidw	MGI:6696117

Genotype
MGI:6696117

cx1

• Allelic Composition: Flot1^em1Xidw/Flot1^em1Xidw; Flot2^em1Xidw/Flot2^em1Xidw
• Genetic Background: FVB-Flot1^em1Xidw Flot2^em1Xidw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:284332 )

N • viable

increased susceptibility to induced morbidity/mortality ( J:284332 )

• increased mortality after induction of SIRS (systemic inflammatory response syndrome) with injection of TNFA + Z-VAD-FMK (a caspase inhibitor)

• normal survival after induction of SIRS (systemic inflammatory response syndrome) with injection of TNFA + Z-VAD-FMK (a caspase inhibitor) when co-injected with RIPK1 inhibitor RIPA-56

growth/size/body

growth/size/body region phenotype ( J:284332 )

N • no gross dysmorphologies or defects