Analysis Tools
behavior/neurological
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• mice fall off an accelerated rotarod more frequently than wild-type mice, however performance is normalized with additional training indicating a deficit in motor skill learning and memory instead of impaired motor coordination
• however, mice show normal grip strength
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• mice are slower to learn to find the submerged platform in acquisition trials and in the probe trail, when the hidden platform is removed, mice cross the original locus of the hidden platform less frequently and swim less time in the target quadrant
• however, mice have normal vision and swimming ability
• SCH23390 and quinpirole treatment accelerates the time to find the submerged platform in the Morris water maze and increases swimming speed and the frequency of crossing the original locus of the hidden platform
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• males are very aggressive after behavioral tests
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• mice are less likely to explore in open areas of an open field arena or in open arms of an elevated plus maze
• mice treated with the D1R antagonist SCH23390 or D2R agonist quinpirole show a gradual increase in the time spent in central areas of the open field
• mice treated with both SCH23390 and quinpirole for 24 hours show an elevation in the time spent in central areas; beneficial effects wane 48 hours after drug administration
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• females, but not males, show less interest in interacting with a novel object
• however, mice are able to recognize or memorize a familiar object
• treatment with both SCH23390 and quinpirole does not change the ability of mice to randomly explore two identical objects or interaction with a novel object
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• females, but not males, show less interest in interacting with a stranger mouse
• however, mice are able to recognize or memorize a familiar cognate
• treatment with both SCH23390 and quinpirole does not change the ability of mice to randomly explore empty chambers or interaction with an unfamiliar cognate
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• mice are hypoactive
• mice treated with both SCH23390 and quinpirole for 24 hours show an elevation in exploratory activities in both travel distance; beneficial effects wane 48 hours after drug administration
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growth/size/body
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• while mice show normal weight gain during preweaning, they gain more weight than wild-type mice after weaning
• females appear overweight earlier than males
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nervous system
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• brain size is normal at birth but becomes smaller at P7 and all later ages
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• corpus callosum is thinner
• corpus callosum atrophy
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• decrease in medulla oblongata volume
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• decrease in the pons volume
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• decrease in hippocampus volume
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• decrease in cerebellum volume
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astrocytosis
(
J:304877
)
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• astrogliosis in the hippocampus and the corpus callosum
• astrogliosis culminates at the radiatum and lacunosum oleculare layers of the hippocampus and the polymorph layer of the dentate gyrus
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• mice show an imbalance between dopamine D1 and D2 receptor containing neurons in the brain, with an elevation of D1R levels and diminished D2R levels
• density of D1R+ neurons in the striatum and nucleus accumbens are increased
• density of D2R+ neurons in the striatum and nucleus accumbens are decreased
• the change in levels of D1R and D2R neurons is detected at P30 but not at P15 or younger ages
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reproductive system
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• females exhibit a decline in reproduction
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• males may be sterile as no pregnancies were obtained when males are mated with wild-type or heterozygous female
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| intellectual disability | DOID:1059 | J:304877 | ||
