Phenotypes associated with this allele

• Allele Symbol: Eif4g1^em1Bjbl
• Allele Name: endonuclease-mediated mutation 1, Benjamin J Blencowe
• Allele ID: MGI:6696153
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eif4g1^em1Bjbl/Eif4g1^em1Bjbl	C57BL/6J-Eif4g1^em1Bjbl	MGI:6696156

Genotype
MGI:6696156

hm1

• Allelic Composition: Eif4g1^em1Bjbl/Eif4g1^em1Bjbl
• Genetic Background: C57BL/6J-Eif4g1^em1Bjbl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:287743 )

N • mice exhibit normal weight, motor coordination, locomotion, habituation, anxiety, aggression, and response to light stimuli

impaired contextual conditioning behavior ( J:287743 )

• mice have impaired episodic memory in the contextual fear-conditioning test, which associates a training context with a foot shock stimulus and requires both hippocampal- and amygdala-dependent memory formation

• however, no difference is seen in the sole amygdala-dependent cued fear conditioning

abnormal social investigation ( J:287743 )

• in the reciprocal interaction test for sociability, mice interact less often than wild-type mice with an age- and sex-matched mouse

abnormal response to social novelty ( J:287743 )

• mice exhibit social behavior abnormalities in the three-chamber apparatus, with mice lacking a social preference in the novelty test

• however, mice do not show a difference in the social preference test

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:287743 )

N • mice exhibit normal hearing

nervous system

enhanced long-term potentiation ( J:287743 )

• CA3-CA1 neurons display a significant facilitation of LTP after induction with multiple tetani that engage the protein-synthesis-dependent form of LTP

• however, activation of LTP via a milder induction protocol which leads to protein-synthesis-independent LTP, fails to induce a significant facilitation of LTP at CA3-CA1 synapses, and mGluR-dependent LTP is unaltered

increased miniature inhibitory postsynaptic current amplitude ( J:287743 )

• CA1 hippocampal neurons show an increase in the amplitude of spontaneous inhibitory postsynaptic currents (sIPSCs), suggesting that neurons have increased inhibitory synaptic conductance

• however, no difference in the frequency or amplitude of miniature (m) and spontaneous (s) excitatory postsynaptic currents (EPSCs) or in the frequency of m/sIPSCs are seen, no differences in intrinsic excitability or in resting membrane potential is seen, and paired-pulse facilitation is unchanged