All Phenotypes Stag2<tm1.1Soga> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Stag2^tm1.1Soga/Y Tg(Mx1-cre)1Cgn/0	involves: C57BL/6J * C57BL/6N * CBA/J	MGI:6696292
cn2	Runx1^tm1Soga/Runx1^tm1Soga Stag2^tm1.1Soga/Y Tg(Mx1-cre)1Cgn/0	involves: C57BL/6J * C57BL/6N * CBA/J	MGI:6696300

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal hematopoietic system morphology/development ( J:289000 )

• pIpC-injected mice exhibit mild myelodysplastic syndrome-like phenotype

• however, overall survival does not differ from wild-type mice

• mice show decreased frequencies of megakaryocyte/erythrocyte lineage-restricted progenitors and erythroid progenitors after pIpC injection, suggesting a blocked differentiation into erythromegakaryocyte lineages

enlarged spleen ( J:289000 )

• slightly enlarged spleen in pIpC-treated mice

extramedullary hematopoiesis ( J:289000 )

• pIpC-injected mice show evidence of extramedullary hematopoiesis, with increased frequencies of erythroid progenitors in the spleen

increased red blood cell distribution width ( J:289000 )

• pIpC-injected mice show increased red cell distribution width, suggestive of dyerythropoiesis

increased granulocyte number ( J:289000 )

• mature cells are skewed to myeloid lineages in pIpC-injected mice with increased granulocytes/monocytes (CD11b+) in the bone marrow and spleen

increased monocyte cell number ( J:289000 )

• mature cells are skewed to myeloid lineages in pIpC-injected mice with increased granulocytes/monocytes (CD11b+) in the bone marrow and spleen

decreased leukocyte cell number ( J:289000 )

• mice show a slightly decreased white blood cell count after polyinosinic-polycytidylic acid (pIpC) injection

• however, no changes in hemoglobin level or platelet count after pIpC injection

decreased B cell number ( J:289000 )

• mice show a large reduction of B-lymphocytes (B220+) after pIpC injection

abnormal hematopoietic precursor cell morphology ( J:289000 )

• hematopoietic stem/progenitor cell pools are expanded in pIpC-injected mice

increased common myeloid progenitor cell number ( J:289000 )

• the increase in LSK cells of pIpC-injected mice is most prominent in myeloid-based progenitors, including multipotent progenitor 2 and 3, followed by long-term hematopoietic stem cells and short-term hematopoietic stem cells, indicating myeloid skewing

increased granulocyte monocyte progenitor cell number ( J:289000 )

• common myeloid progenitors and granulocyte-macrophage progenitors are increased in pIpC-treated mice

decreased common lymphocyte progenitor cell number ( J:289000 )

• common lymphoid progenitors are decreased in pIpC-treated mice

decreased erythroid progenitor cell number ( J:289000 )

• mice show decreased frequency of erythroid progenitors after pIpC injection

increased hematopoietic stem cell number ( J:289000 )

• bone marrow of pIpC-injected mice shows higher frequency of Lin-/Sca1+/c-Kit+ (LSK) cells, where all major subfractions of LSK cells are increased

decreased megakaryocyte-erythroid progenitor cell number ( J:289000 )

• mice show decreased frequencies of megakaryocyte/erythrocyte lineage-restricted progenitors following pIpC injection

abnormal hematopoietic stem cell physiology ( J:289000 )

• hematopoietic stem cells (CD150+/CD48- LSK) show a decreased frequency of apoptotic cells and an enhanced cell cycling (S/G2/M) with decreased quiescent cells after pIpC injection

• in competitive repopulation assay, cells from pIpC-injected mice show enhanced chimerism within the LSK fraction, although the chimerism is not changed in total bone marrow and even reduced in peripheral blood, particularly within lymphocytes, indicating an enhanced self-renewal and repopulation capacity of progenitors with a block in lymphoid differentiation

immune system

enlarged spleen ( J:289000 )

• slightly enlarged spleen in pIpC-treated mice

increased granulocyte number ( J:289000 )

• mature cells are skewed to myeloid lineages in pIpC-injected mice with increased granulocytes/monocytes (CD11b+) in the bone marrow and spleen

increased monocyte cell number ( J:289000 )

• mature cells are skewed to myeloid lineages in pIpC-injected mice with increased granulocytes/monocytes (CD11b+) in the bone marrow and spleen

decreased leukocyte cell number ( J:289000 )

• mice show a slightly decreased white blood cell count after polyinosinic-polycytidylic acid (pIpC) injection

• however, no changes in hemoglobin level or platelet count after pIpC injection

decreased B cell number ( J:289000 )

• mice show a large reduction of B-lymphocytes (B220+) after pIpC injection

growth/size/body

enlarged spleen ( J:289000 )

• slightly enlarged spleen in pIpC-treated mice

Allelic Composition	Runx1^tm1Soga/Runx1^tm1Soga Stag2^tm1.1Soga/Y Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: C57BL/6J * C57BL/6N * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1^tm1Soga mutation (0 available); any Runx1 mutation (34 available)
Stag2^tm1.1Soga mutation (0 available); any Stag2 mutation (15 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

anemia ( J:289000 )

• lethally irradiated mice transplanted with mutant bone marrow cells followed by pIpC injection develop anemia with increased mean corpuscular volume and red blood cell distribution width

decreased leukocyte cell number ( J:289000 )

• lethally irradiated mice transplanted with mutant bone marrow cells followed by pIpC injection exhibit reduced white blood cell count, with a reduction in lymphocytes, granulocytes, and monocytes

increased hematopoietic stem cell number ( J:289000 )

• lethally irradiated mice transplanted with mutant bone marrow cells followed by pIpC injection exhibit increased frequency of immature bone marrow progenitors (LSK cells)

abnormal myeloid cell morphology ( J:289000 )

• lethally irradiated mice transplanted with mutant bone marrow cells followed by pIpC injection exhibit lineage-committed mature cells that are skewed to myeloid lineages

decreased erythroid progenitor cell number ( J:289000 )

• lethally irradiated mice transplanted with mutant bone marrow cells followed by pIpC injection show reduced frequency of colony-forming unit erythroid cells and Ter119+CD71+ erythroid progenitors

increased mean corpuscular volume ( J:289000 )

• lethally irradiated mice transplanted with mutant bone marrow cells followed by pIpC injection show increased mean corpuscular volume

increased red blood cell distribution width ( J:289000 )

• lethally irradiated mice transplanted with mutant bone marrow cells followed by pIpC injection show increased red blood cell distribution width

abnormal bone marrow cell physiology ( J:289000 )

• all lethally irradiated mice transplanted with mutant-derived bone marrow, followed by pIpC injection, develop overt myelodysplastic syndrome, mostly within half a year after pIpC injection, with severe cytopenia and marked trilineage dysplasia

immune system

decreased leukocyte cell number ( J:289000 )

• lethally irradiated mice transplanted with mutant bone marrow cells followed by pIpC injection exhibit reduced white blood cell count, with a reduction in lymphocytes, granulocytes, and monocytes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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