Phenotypes associated with this allele

• Allele Symbol: Tecpr2^em1Wei
• Allele Name: endonuclease-mediated mutation 1, Weizmann Institute of Science
• Allele ID: MGI:6696317
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tecpr2^em1Wei/Tecpr2^em1Wei	C57BL/6J-Tecpr2^em1Wei	MGI:6711061

Genotype
MGI:6711061

hm1

• Allelic Composition: Tecpr2^em1Wei/Tecpr2^em1Wei
• Genetic Background: C57BL/6J-Tecpr2^em1Wei

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:304963 )

N • mice exhibit normal home cage locomotor activity or coordination and balance performance in a rotarod test

abnormal gait ( J:304963 )

• significantly smaller base of support with smaller front paws contact and larger hind paws print width

increased mechanical nociceptive threshold ( J:304963 )

• when tested with Von Frey hair filaments

decreased thermal nociceptive threshold ( J:304963 )

nervous system

neurodegeneration ( J:304963 )

• in the central brain system at 4 to 5 months

axonal dystrophy ( J:304963 )

• with bilateral and symmetrical axonal swelling (spheroids) in the medulla oblongata

• age-dependent with significance beginning at 6 months

axonal spheroids ( J:304963 )

• in the brain stem and thoracic spinal cord

cellular

impaired autophagy ( J:304963 )

• age-dependent accumulation of autophagosomes

homeostasis/metabolism

impaired autophagy ( J:304963 )

• age-dependent accumulation of autophagosomes