Analysis Tools
neoplasm
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• mice injected with Lewis lung carcinoma subcutaneous tumor cells or 1956 sarcoma subcutaneous tumor cells show reduced counts of tumor vessels
• lethally irradiated homozygous mutant recipient mice receiving bone marrow transplantation from wild-type donors exhibit impaired vascular network formation in tumors
• mice injected with 1956 sarcoma subcutaneous tumor cells develop more intratumoral high endothelial venules compared to wild-type mice
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• mice injected with Lewis lung carcinoma subcutaneous tumor cells or 1956 sarcoma subcutaneous tumor cells show retarded tumor growth compared to wild-type mice, with reduced counts of tumor vessels
• lethally irradiated homozygous mutant recipient mice receiving bone marrow transplantation from wild-type donors exhibit impaired tumor growth and vascular network formation
• however, wild-type lethally irradiated recipient mice transplanted with bone marrow from mutant homozygous donor mice exhibit tumor growth comparable to wild-type mice
• mice injected with 1956 sarcoma subcutaneous tumor cells exhibit an antitumor immune microenvironment, with increased CD8+ cytotoxic T lymphocytes, decreased Treg cells, increased M1 macrophages and decreased M2 macrophages
• tumor-bearing mice treated with neutralizing antibodies to deplete CD4+ and CD8+ T cell compartments or with IFN-gamma neutralizing antibody show abrogated tumor growth restriction
• 1956 sarcoma subcutaneous tumor cell-transplanted mice bearing tumors treated with a late-onset anti-PD1 immunotherapy show marked tumor regression
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cardiovascular system
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• mice appear normal and exhibit histologically regular vasculature in different organ beds and cardiovascular parameters, normal compliance profiles of the ascending aorta and carotid artery, and similar cardiac functions as wild-type mice
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• in a hindlimb ischemia injury model, mice have a lower blood perfusion recovery and neovascularization of the injured area compared to wild-type mice
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• mice injected with Lewis lung carcinoma subcutaneous tumor cells or 1956 sarcoma subcutaneous tumor cells show reduced counts of tumor vessels
• lethally irradiated homozygous mutant recipient mice receiving bone marrow transplantation from wild-type donors exhibit impaired vascular network formation in tumors
• mice injected with 1956 sarcoma subcutaneous tumor cells develop more intratumoral high endothelial venules compared to wild-type mice
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hematopoietic system
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• tumors in mice injected with 1956 sarcoma subcutaneous tumor cells exhibit an increase of CD8+ cytotoxic T lymphocytes
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• tumors in mice injected with 1956 sarcoma subcutaneous tumor cells exhibit a decrease of immunosuppressive regulatory T (Treg) cells
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• tumors in mice injected with 1956 sarcoma subcutaneous tumor cells exhibit an increased M1 macrophage population and a decreased M2 macrophage population, with increased M1-to-M2 ratios
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immune system
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• tumors in mice injected with 1956 sarcoma subcutaneous tumor cells exhibit an increase of CD8+ cytotoxic T lymphocytes
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• tumors in mice injected with 1956 sarcoma subcutaneous tumor cells exhibit a decrease of immunosuppressive regulatory T (Treg) cells
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• tumors in mice injected with 1956 sarcoma subcutaneous tumor cells exhibit an increased M1 macrophage population and a decreased M2 macrophage population, with increased M1-to-M2 ratios
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