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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mmdtm1Beij
targeted mutation 1, Chinese Academy of Sciences
MGI:6696444
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mmdtm1Beij/Mmdtm1Beij Not Specified MGI:6696445


Genotype
MGI:6696445
hm1
Allelic
Composition
Mmdtm1Beij/Mmdtm1Beij
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmdtm1Beij mutation (0 available); any Mmd mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thioglycolate-injected mice exhibit less of an increase in peritoneal Ly6C-F4/80+ macrophage compared with similarly treated wild-type mice
• reduced mature macrophage in M-CSF-treated mice than in similarly treated wild-type mice
• however, macrophage polarization is normal
• in mice treated with chicken type II collagen
• mice treated with chicken type II collagen exhibit reduced clinical scores of arthritis and reduced symptoms with reduced tissue damage and inflammation compared with similarly treated wild-type mice

skeleton
• mice treated with chicken type II collagen exhibit reduced clinical scores of arthritis and reduced symptoms with reduced tissue damage and inflammation compared with similarly treated wild-type mice

cellular
• thioglycolate-injected mice exhibit less of an increase in peritoneal Ly6C-F4/80+ macrophage compared with similarly treated wild-type mice
• reduced mature macrophage in M-CSF-treated mice than in similarly treated wild-type mice
• however, macrophage polarization is normal

hematopoietic system
• thioglycolate-injected mice exhibit less of an increase in peritoneal Ly6C-F4/80+ macrophage compared with similarly treated wild-type mice
• reduced mature macrophage in M-CSF-treated mice than in similarly treated wild-type mice
• however, macrophage polarization is normal





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory