Analysis Tools
nervous system
|
• T-type calcium inward current in thalamic reticular nucleus neurons is mostly absent
• rebound burst firing in thalamic reticular nucleus neurons is largely absent, although neurons occasionally show rebound burst firing at holding potentials more depolarized than -60 mV but these bursts contain fewer action potentials, with reduced frequency
• however, no differences are seen in the high-voltage-activated inward current
|
|
• significant reductions in the maximum action potential frequency in the first burst are seen during rebound burst firing in thalamic reticular nucleus neurons compared to wild-type mice
|
|
• during rebound burst firing, thalamic reticular nucleus shows reduced after hyperpolarization potential of the first burst
• however, tonic firing of thalamic reticular nucleus neurons is intact
|
|
• during NREM, EEG shows reduced power spectral density in the sigma range, with a maximal difference of 11 Hz, reduced sigma (11-15 Hz) band relative power, increased power at lower frequencies, in particular delta range (3-5 Hz)
• the increase in NREM delta frequency is also present during REM, as is the decrease in sigma power, although to a lesser extent
|
|
• thalamic reticular nucleus neurons show a reduction of NREM sleep spindle density
• the reductions in spindle density during NREM are pronounced prior to NREM/REM transitions
• for Fc = 11 Hz NREM spindles, spindle durations and spindle-wise measures of integrated spindle activity are reduced indicating not only differences in spindle number but also smaller spindles
|
