Phenotypes associated with this allele

• Allele Symbol: Cacna1i^em2Jqp
• Allele Name: endonuclease-mediated mutation 2, Jen Q Pan
• Allele ID: MGI:6704922
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacna1i^em2Jqp/Cacna1i^em2Jqp	Not Specified	MGI:6704924

Genotype
MGI:6704924

hm1

• Allelic Composition: Cacna1i^em2Jqp/Cacna1i^em2Jqp
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system electrophysiology ( J:302192 )

• mice show a reduction in the peak T-type calcium current density

• mice show a reduction of rebound burst firing in thalamic reticular nucleus neurons, showing a reduction in the average number and frequency of the bursts between -65 and -50 mV and in the maximum number of bursts elicited

• however, no differences are seen in the high-voltage-activated inward current

abnormal action potential ( J:302192 )

• significant reductions in the maximum action potential frequency in the first burst are seen during rebound burst firing in thalamic reticular nucleus neurons compared to wild-type mice

• significant reduction in the action potential frequency and average number of action potentials are seen in the second burst during repetitive bursting

abnormal afterhyperpolarization ( J:302192 )

• during rebound burst firing, thalamic reticular nucleus shows reduced after hyperpolarization potential of the first burst

• however, inter-burst interval is similar to wild-type mice

abnormal single cell response ( J:302192 )

• thalamic reticular nucleus neurons show a reduction of NREM sleep spindle density

• the reductions in spindle density during NREM are pronounced prior to NREM/REM transitions

• for Fc = 11 Hz NREM spindles, spindle durations and spindle-wise measures of integrated spindle activity are reduced indicating not only differences in spindle number but also smaller spindles