All Phenotypes Tor1b<tm1.2Wtd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tor1b^tm1.2Wtd
targeted mutation 1.2, William T Dauer
MGI:6705130

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tor1a^tm1Wtd/Tor1a^tm3.1Wtd Tor1b^tm1.2Wtd/Tor1b^tm1.1Wtd Emx1^tm1(cre)Krj/Emx1⁺	involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * C57BL/6J	MGI:6710955
cn2	Tor1a^tm2Wtd/Tor1a^tm3.1Wtd Tor1b^tm1.2Wtd/Tor1b⁺ Emx1^tm1(cre)Krj/Emx1⁺	involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * C57BL/6J	MGI:6710960
cn3	Tor1a^tm2Wtd/Tor1a^tm3.1Wtd Tor1b^tm1.2Wtd/Tor1b^tm1.2Wtd Emx1^tm1(cre)Krj/Emx1⁺	involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * C57BL/6J	MGI:6710961

Allelic Composition	Tor1a^tm1Wtd/Tor1a^tm3.1Wtd Tor1b^tm1.2Wtd/Tor1b^tm1.1Wtd Emx1^tm1(cre)Krj/Emx1⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Tor1a^tm1Wtd mutation (1 available); any Tor1a mutation (24 available)
Tor1a^tm3.1Wtd mutation (1 available); any Tor1a mutation (24 available)
Tor1b^tm1.1Wtd mutation (1 available); any Tor1b mutation (20 available)
Tor1b^tm1.2Wtd mutation (0 available); any Tor1b mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:288753 )

• mice exhibit early lethality beginning in the third postnatal week and endpoint of survival is P28

growth/size/body

postnatal growth retardation ( J:288753 )

• mice show reduced postnatal growth

nervous system

thin cerebral cortex ( J:288753 )

• cerebral cortex is thinner at P28, with a 64.8% reduction compared to 10.4% reduction in single conditional Tor1a homozygous mutant mice

• mice exhibit reductions of CUX1+ (cortical layer II-IV) and CTIP2+ (cortical layer V-VI) cortical neurons in sensorimotor cortex

• however, no overt brain structural abnormalities are seen at birth, cortical thickness is normal at birth, and the number of CTIP2+ (cortical layer V-VI) cortical neurons are not different at P0

gliosis ( J:288753 )

• mice exhibit gliosis in the cerebral cortex and hippocampus at P28

neurodegeneration ( J:288753 )

• mice exhibit cell loss in the cerebral cortex and hippocampus at P28

Allelic Composition	Tor1a^tm2Wtd/Tor1a^tm3.1Wtd Tor1b^tm1.2Wtd/Tor1b⁺ Emx1^tm1(cre)Krj/Emx1⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Tor1a^tm2Wtd mutation (1 available); any Tor1a mutation (24 available)
Tor1a^tm3.1Wtd mutation (1 available); any Tor1a mutation (24 available)
Tor1b^tm1.2Wtd mutation (0 available); any Tor1b mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

limb grasping ( J:288753 )

• mice show increased limb clasping in the tail suspension test

nervous system

thin cerebral cortex ( J:288753 )

• cortical thickness is reduced

• however, CUX1+ (cortical layer II-IV) and CTIP2+ (cortical layer V-VI) cortical neuron counts are normal

Allelic Composition	Tor1a^tm2Wtd/Tor1a^tm3.1Wtd Tor1b^tm1.2Wtd/Tor1b^tm1.2Wtd Emx1^tm1(cre)Krj/Emx1⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

thin cerebral cortex ( J:288753 )

• cortical thickness is normal at birth but is dramatically reduced by P28, with mice showing a nonsignificant reduction of CUX1+ (cortical layer II-IV) cortical neurons and a significant reduction of CTIP2+ (cortical layer V-VI) cortical neurons at P28

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