Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{em1(Tor1b)Wtd}
• Allele Name: endonuclease-mediated mutation 1, William T Dauer
• Allele ID: MGI:6710954
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^em1(Tor1b)Wtd/Gt(ROSA)26Sor^+ Tg(dlx5a-cre)1Mekk/0	involves: 129 * C57BL/6 * CD-1	MGI:6710965
cn2	Gt(ROSA)26Sor^em1(Tor1b)Wtd/Gt(ROSA)26Sor^+ Tg(Nes-cre)1Kln/0	involves: 129 * C57BL/6 * SJL	MGI:6710963
cn3	Gt(ROSA)26Sor^em1(Tor1b)Wtd/Gt(ROSA)26Sor^+ Tor1a^tm1Wtd/Tor1a^tm3.1Wtd Tg(dlx5a-cre)1Mekk/0	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * CD-1	MGI:6710971
cn4	Gt(ROSA)26Sor^em1(Tor1b)Wtd/Gt(ROSA)26Sor^+ Tor1a^tm1Wtd/Tor1a^tm3.1Wtd Tg(Nes-cre)1Kln/0	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * SJL	MGI:6710962
cn5	Gt(ROSA)26Sor^em1(Tor1b)Wtd/Gt(ROSA)26Sor^+ Tor1a^tm2Wtd/Tor1a^tm3.1Wtd Tg(Nes-cre)1Kln/0	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * SJL	MGI:6710964

Genotype
MGI:6710965

cn1

• Allelic Composition: Gt(ROSA)26Sor^{em1(Tor1b)Wtd}/Gt(ROSA)26Sor⁺; Tg(dlx5a-cre)1Mekk/0
• Genetic Background: involves: 129 * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:288753 )

N • mice show normal postnatal growth and survival, and normal juvenile reflexes, including negative geotaxis, surface righting, and forelimb hang

Genotype
MGI:6710963

cn2

• Allelic Composition: Gt(ROSA)26Sor^{em1(Tor1b)Wtd}/Gt(ROSA)26Sor⁺; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129 * C57BL/6 * SJL

growth/size/body

decreased body weight ( J:288753 )

• decreased body weight before P56

behavior/neurological

behavior/neurological phenotype ( J:288753 )

N • mice do not show overt motor abnormalities

mortality/aging

mortality/aging ( J:288753 )

N • mice show normal survival

nervous system

nervous system phenotype ( J:288753 )

N • brain morphology and size appear normal

Genotype
MGI:6710971

cn3

• Allelic Composition: Gt(ROSA)26Sor^{em1(Tor1b)Wtd}/Gt(ROSA)26Sor⁺; Tor1a^tm1Wtd/Tor1a^tm3.1Wtd; Tg(dlx5a-cre)1Mekk/0
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * CD-1

behavior/neurological

behavior/neurological phenotype ( J:288753 )

N • mice show rescue of the limb clasping phenotype and the twisting movements seen in Tor1a^tm1Wtd/Tor1a^tm3.1Wtd Tg(Dlx5a-cre)1Mekk/0 mice

nervous system

nervous system phenotype ( J:288753 )

N • mice show prevention of striatal cholinergic interneuron degeneration that occurs in Tor1a^tm1Wtd/Tor1a^tm3.1Wtd Tg(Dlx5a-cre)1Mekk/0 mice

Genotype
MGI:6710962

cn4

• Allelic Composition: Gt(ROSA)26Sor^{em1(Tor1b)Wtd}/Gt(ROSA)26Sor⁺; Tor1a^tm1Wtd/Tor1a^tm3.1Wtd; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * SJL

normal phenotype

no abnormal phenotype detected ( J:288753 )

• mice do not exhibit lethality, growth defects, or abnormal twisting movements or stiff postures, and exhibit normal brain with no gliosis

Genotype
MGI:6710964

cn5

• Allelic Composition: Gt(ROSA)26Sor^{em1(Tor1b)Wtd}/Gt(ROSA)26Sor⁺; Tor1a^tm2Wtd/Tor1a^tm3.1Wtd; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * SJL

behavior/neurological

behavior/neurological phenotype ( J:288753 )

N • mice show almost complete rescue of the abnormal postural (squinty eyes and twisted hindpaws) and development phenotypes seen in Tor1a^tm2Wtd/Tor1a^tm3.1Wtd Tg(Nes-cre)1Kln/0 mice

growth/size/body

growth/size/body region phenotype ( J:288753 )

N • mice exhibit partial rescue of the postnatal growth retardation seen in Tor1a^tm2Wtd/Tor1a^tm3.1Wtd Tg(Nes-cre)1Kln/0 mice from P8 to P28 and are fully restored to normal weight by P56

nervous system

nervous system phenotype ( J:288753 )

N • mice do not exhibit neurodegeneration or gliosis