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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Impacttm1.1Casb
targeted mutation 1.1, Beatriz A Castilho
MGI:6710957
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Impacttm1.1Casb/Impacttm1.1Casb involves: C57BL/6J MGI:6710958
cx2
Eif2ak4tm1Drc/Eif2ak4tm1Drc
Impacttm1.1Casb/Impacttm1.1Casb
involves: 129S6/SvEvTac * C57BL/6J MGI:6710959


Genotype
MGI:6710958
hm1
Allelic
Composition
Impacttm1.1Casb/Impacttm1.1Casb
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Impacttm1.1Casb mutation (0 available); any Impact mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• maintain a lean phenotype on a high fat diet
• after an 18h fast
• however, fed glucose levels are similar to controls
• drastically reduced after 18 hr of fasting but returns to normal after refeeding
• slightly lower body temperature in response to a cold environment but do adjust body temperature in response to a cold environment
• during the dark phase
• after 11 and 12 weeks on a high fat diet

adipose tissue
• on normal chow and a high fat diet

behavior/neurological
• on a high fat diet

growth/size/body
• maintain a lean phenotype on a high fat diet




Genotype
MGI:6710959
cx2
Allelic
Composition
Eif2ak4tm1Drc/Eif2ak4tm1Drc
Impacttm1.1Casb/Impacttm1.1Casb
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak4tm1Drc mutation (0 available); any Eif2ak4 mutation (89 available)
Impacttm1.1Casb mutation (0 available); any Impact mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• maintain a lean phenotype on a high fat diet
• reduced after 18 hr of fasting but returns to normal after refeeding
• decrease in body temperature induced by fasting is less than in Impact single homozygous mice

growth/size/body
• maintain a lean phenotype on a high fat diet





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory