Analysis Tools
homeostasis/metabolism
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• mice fed a high-fat diet from 6 to 20 weeks after birth are resistant to obesity
• however, total consumption of high fat diet is about the same as in wild-type mice
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• mice fed a high-fat diet do not show the increase of total cholesterol as seen in wild-type mice
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• the high-fat diet-induced increase in blood triglyceride seen in wild-type mice is significantly ameliorated in mutant mice
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• high-fat diet-fed mice show increased rectal temperature compared to wild-type mice
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adipose tissue
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• mice fed a high-fat diet exhibit a thinner adipose layer in back skin sections compared to wild-type mice
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• mice fed a standard diet exhibit a thinner layer of dorsal skin and less adipose tissue at 4 and 8 weeks of age, a time in which wild-type mice show grossly expanded subcutaneous adipose tissue, but this difference becomes negligible at 12 weeks of age, indicating abnormal adipogenesis
• adipogenic progenitor cells fail to accumulate lipid raft/caveolin around elongated cilia during adipogenesis
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• males and females fed a high-fat diet exhibit less enlargement of visceral fat mass than seen in wild-type mice
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• dermal adipogenic progenitor cells exhibit elongated cilia
• adipogenic progenitor cells from the skin of 8-week-old mice subjected to adipogenic differentiation show significantly inhibited cilia resorption and lipid droplet formation; individual adipogenic progenitor cells still have their cilia after adipogenic stimulation and tend not to produce lipid droplets
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• mice fed a high-fat diet exhibit smaller adipocytes in back skin sections compared to wild-type mice
• high-fat diet fed mice show smaller fat cell size of epididymal white adipose tissue compared to wild-type mice
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• the infiltration of inflammatory M1, but not anti-inflammatory M2, macrophages into epididymal white adipose tissue is blocked in high-fat diet-fed mice compared to controls which show both infiltration of M1 and M2 macrophages
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growth/size/body
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• males and females fed a high-fat diet exhibit less enlargement of visceral fat mass than seen in wild-type mice
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• mice fed a high-fat diet from 6 to 20 weeks after birth are resistant to obesity
• however, total consumption of high fat diet is about the same as in wild-type mice
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liver/biliary system
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• mice are protected from high-fat diet-induced hepatic lipid accumulation
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cellular
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• dermal adipogenic progenitor cells exhibit elongated cilia
• adipogenic progenitor cells from the skin of 8-week-old mice subjected to adipogenic differentiation show significantly inhibited cilia resorption and lipid droplet formation; individual adipogenic progenitor cells still have their cilia after adipogenic stimulation and tend not to produce lipid droplets
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