Phenotypes associated with this allele

• Allele Symbol: Dyrk2^tm1.1Kyos
• Allele Name: targeted mutation 1.1, Kiyotsugu Yoshida
• Allele ID: MGI:6711272
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dyrk2^tm1.1Kyos/Dyrk2^tm1.1Kyos	involves: C57BL/6J * C57BL/6N	MGI:6711382

Genotype
MGI:6711382

hm1

• Allelic Composition: Dyrk2^tm1.1Kyos/Dyrk2^tm1.1Kyos
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

absent basioccipital bone ( J:298652 )

• in E18.5 embryos

absent basisphenoid bone ( J:298652 )

• in E18.5 embryos

absent presphenoid bone ( J:298652 )

• in E18.5 embryos

sternebra fusion ( J:298652 )

• in E18.5 embryos

vertebral fusion ( J:298652 )

• in E18.5 embryos

decreased bone mineralization ( J:298652 )

• in E16.5 embryos

mortality/aging

perinatal lethality, complete penetrance ( J:298652 )

digestive/alimentary system

cleft palate ( J:298652 )

• in E18.5 embryos

tongue hypoplasia ( J:298652 )

• in E18.5 embryos

growth/size/body

cleft palate ( J:298652 )

• in E18.5 embryos

tongue hypoplasia ( J:298652 )

• in E18.5 embryos

short snout ( J:298652 )

• short dorsum in E18.5 embryos

limbs/digits/tail

short limbs ( J:298652 )

• in E18.5 embryos

craniofacial

absent basioccipital bone ( J:298652 )

• in E18.5 embryos

absent basisphenoid bone ( J:298652 )

• in E18.5 embryos

absent presphenoid bone ( J:298652 )

• in E18.5 embryos

cleft palate ( J:298652 )

• in E18.5 embryos

tongue hypoplasia ( J:298652 )

• in E18.5 embryos

short snout ( J:298652 )

• short dorsum in E18.5 embryos

cellular

abnormal primary cilium morphology ( J:298652 )

• significantly longer cilia in mouse embryo fibroblasts (MEFs) and E10.5 embryos

• mouse embryo fibroblast (MEF) and E10.5 embryo cilia often tapered, twisted or with bulged tip

• normal proportion of ciliated cells in mouse embryo fibroblasts (MEFs)