Phenotypes associated with this allele

• Allele Symbol: Caskin2^tm1.1Lasb
• Allele Name: targeted mutation 1.1, Laszlo Buday
• Allele ID: MGI:6711392
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Caskin1^tm1.1Lasb/Caskin1^tm1.1Lasb Caskin2^tm1.1Lasb/Caskin2^tm1.1Lasb	involves: C57BL/6J * C57BL/6N	MGI:6711395

Genotype
MGI:6711395

cx1

• Allelic Composition: Caskin1^tm1.1Lasb/Caskin1^tm1.1Lasb; Caskin2^tm1.1Lasb/Caskin2^tm1.1Lasb
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:297862 )

N • normal distance traveled and average speed in open field test at ages 2-5, 5-7 and 7-13 months

impaired spatial learning ( J:297862 )

• no increased swimming towards (removed or relocated) platform location through the course of the Morris water maze test at age 2.5-5 months

abnormal response to novel object ( J:297862 )

• no difference in interest between novel and familiar object at ages 2-5, 5-7 and 7-13 months

nervous system

nervous system phenotype ( J:297862 )

N • normal synaptic release or postsynaptic current formation under activity deprived conditions in vitro in dissociated hippocampal neuronal cultures

abnormal hippocampal pyramidal neuron dendrite morphology ( J:297862 )

• significantly reduced active zone length, spine area and length of postsynaptic density within spine heads and more rounded spines in hippocampal CA1 pyramidal neurons

reduced long-term potentiation ( J:297862 )

• reduced elevation of population spike (POPS) in hippocampal CA1 pyramidal neurons after 100 Hz HFS stimulus