About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mmrn2tm1Monm
targeted mutation 1, Maurizio Mongiat
MGI:6711429
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mmrn2tm1Monm/Mmrn2tm1Monm involves: C57BL/6NCrl MGI:6711430


Genotype
MGI:6711430
hm1
Allelic
Composition		 Mmrn2tm1Monm/Mmrn2tm1Monm
Genetic
Background		 involves: C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmrn2tm1Monm mutation (0 available); any Mmrn2 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina blood vessel morphology ( J:298039 )
• retinal vessels show abnormal VE-cadherin distribution, frequent indistinguishable endothelial cell contacts, and impaired pericyte coverage
abnormal tumor vascularization ( J:298039 )
• increase in the density of small vessels in B16F10 melanoma cell tumors
increased vascular permeability ( J:298039 )
• in retinal blood vessels and in vessels in B16F10 melanoma cell tumors

neoplasm
abnormal tumor vascularization ( J:298039 )
• increase in the density of small vessels in B16F10 melanoma cell tumors

vision/eye
abnormal retina blood vessel morphology ( J:298039 )
• retinal vessels show abnormal VE-cadherin distribution, frequent indistinguishable endothelial cell contacts, and impaired pericyte coverage




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory