Phenotypes associated with this allele

• Allele Symbol: Scgn^em1Ezb
• Allele Name: endonuclease-mediated mutation 1, Ezra Burstein
• Allele ID: MGI:6711490
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scgn^em1Ezb/Scgn^em1Ezb	C57BL/6-Scgn^em1Ezb	MGI:6711502

Genotype
MGI:6711502

hm1

• Allelic Composition: Scgn^em1Ezb/Scgn^em1Ezb
• Genetic Background: C57BL/6-Scgn^em1Ezb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:285572 )

N • normal colonic epithelium histology

N • no colitis up to age 330 days

increased susceptibility to colitis induced morbidity/mortality ( J:285572 )

♂ • greater weight loss, elevated disease severity score, increased mortality and increased tissue damage after DSS administration

growth/size/body

growth/size/body region phenotype ( J:285572 )

N • no obvious phenotype

hematopoietic system

hematopoietic system phenotype ( J:285572 )

N • normal numbers and composition of colonic and small bowel lamina propria leukocyte populations

immune system

increased susceptibility to colitis induced morbidity/mortality ( J:285572 )

♂ • greater weight loss, elevated disease severity score, increased mortality and increased tissue damage after DSS administration

mortality/aging

mortality/aging ( J:285572 )

N • viable

increased susceptibility to colitis induced morbidity/mortality ( J:285572 )

♂ • greater weight loss, elevated disease severity score, increased mortality and increased tissue damage after DSS administration