Phenotypes associated with this allele

• Allele Symbol: Scgn^em2Ezb
• Allele Name: endonuclease-mediated mutation 2, Ezra Burstein
• Allele ID: MGI:6711491
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scgn^em2Ezb/Scgn^em2Ezb	C57BL/6-Scgn^em2Ezb	MGI:6711504

Genotype
MGI:6711504

hm1

• Allelic Composition: Scgn^em2Ezb/Scgn^em2Ezb
• Genetic Background: C57BL/6-Scgn^em2Ezb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:285572 )

• normal colonic epithelium histology

• no colitis up to age 330 days

increased susceptibility to colitis induced morbidity/mortality ( J:285572 )

♂ • greater weight loss, elevated disease severity score, increased mortality and increased tissue damage after DSS administration

growth/size/body

growth/size/body region phenotype ( J:285572 )

• no obvious phenotype

immune system

increased susceptibility to colitis induced morbidity/mortality ( J:285572 )

♂ • greater weight loss, elevated disease severity score, increased mortality and increased tissue damage after DSS administration

mortality/aging

mortality/aging ( J:285572 )

• viable

increased susceptibility to colitis induced morbidity/mortality ( J:285572 )

♂ • greater weight loss, elevated disease severity score, increased mortality and increased tissue damage after DSS administration