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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prss50em1Cajj
endonuclease-mediated mutation 1, Carolina J Jorgez
MGI:6711590
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prss50em1Cajj/Prss50em1Cajj involves: C57BL/6J MGI:6711591


Genotype
MGI:6711591
hm1
Allelic
Composition		 Prss50em1Cajj/Prss50em1Cajj
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss50em1Cajj mutation (0 available); any Prss50 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm axoneme morphology ( J:305434 )
• with multiple tails; axonemes with swollen mitochondria and organelle disorganization
absent sperm flagellum ( J:305434 )
• in some sperm
multiflagellated sperm ( J:305434 )
• sperm with multiple tails
multi-headed sperm ( J:305434 )
• sperm with multiple heads
abnormal spermatid morphology ( J:305434 )
• with impaired cell division, increased phagocytic vesicles and centriole defects
decreased sperm progressive motility ( J:305434 )
• significant reduction in progressive sperm motility
asthenozoospermia ( J:305434 )
• significant reduction in total sperm motility
decreased hyperactivated sperm motility ( J:305434 )
• significant reduction in hyperactivated sperm motility
immotile sperm ( J:305434 )
• significant increase in % of static sperm
abnormal seminiferous tubule morphology ( J:305434 )
• seminiferous tubules exhibit missing several types of germ cell or lacking all germ cells with a high degree of vacuolation, multinucleated and symplastic spermatids, and residual bodies unlike in wild-type mice
decreased litter size ( J:305434 )
• from male mice
male infertility ( J:305434 )
• some male mice are infertile with the majority sub-fertile
reduced male fertility ( J:305434 )
• some male mice are infertile with the majority sub-fertile

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:305434 )
N
• mice exhibit normal serum levels of testosterone, follicle stimulating hormone, and luteinizing hormone

cellular
abnormal sperm axoneme morphology ( J:305434 )
• with multiple tails; axonemes with swollen mitochondria and organelle disorganization
absent sperm flagellum ( J:305434 )
• in some sperm
multiflagellated sperm ( J:305434 )
• sperm with multiple tails
multi-headed sperm ( J:305434 )
• sperm with multiple heads
abnormal spermatid morphology ( J:305434 )
• with impaired cell division, increased phagocytic vesicles and centriole defects
decreased sperm progressive motility ( J:305434 )
• significant reduction in progressive sperm motility
asthenozoospermia ( J:305434 )
• significant reduction in total sperm motility
decreased hyperactivated sperm motility ( J:305434 )
• significant reduction in hyperactivated sperm motility
immotile sperm ( J:305434 )
• significant increase in % of static sperm

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:305434 )
• seminiferous tubules exhibit missing several types of germ cell or lacking all germ cells with a high degree of vacuolation, multinucleated and symplastic spermatids, and residual bodies unlike in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory