All Phenotypes Mrnip<em1Nju> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mrnip^em1Nju
endonuclease-mediated mutation 1, Model Animal Research Center of Nanjing University
MGI:6711595

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mrnip^em1Nju/Mrnip^em1Nju	involves: CD-1	MGI:6711613

Allelic Composition	Mrnip^em1Nju/Mrnip^em1Nju
Genetic Background	involves: CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrnip^em1Nju mutation (0 available); any Mrnip mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal chromosomal synapsis ( J:305295 )

• in male germ cells

asthenozoospermia ( J:305295 )

abnormal seminiferous tubule epithelium morphology ( J:305295 )

• shrunk with presence of vacuolation and multinuclear giant cells

• however, the number of spermatogonial stem cells and Sertoli cells is normal

small seminiferous tubules ( J:305295 )

small testis ( J:305295 )

decreased testis weight ( J:305295 )

abnormal spermatogenesis ( J:305295 )

oligozoospermia ( J:305295 )

abnormal male meiosis ( J:305295 )

• reduced pachytene and diplotene spermatocytes with impaired meiotic double strand break repair, chromosome synapsis, and homologous recombination

decreased litter size ( J:305295 )

reduced male fertility ( J:305295 )

cellular

oligozoospermia ( J:305295 )

abnormal chromosomal synapsis ( J:305295 )

• in male germ cells

abnormal male meiosis ( J:305295 )

• reduced pachytene and diplotene spermatocytes with impaired meiotic double strand break repair, chromosome synapsis, and homologous recombination

asthenozoospermia ( J:305295 )

endocrine/exocrine glands

abnormal seminiferous tubule epithelium morphology ( J:305295 )

• shrunk with presence of vacuolation and multinuclear giant cells

• however, the number of spermatogonial stem cells and Sertoli cells is normal

small seminiferous tubules ( J:305295 )

small testis ( J:305295 )

decreased testis weight ( J:305295 )

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