Phenotypes associated with this allele

• Allele Symbol: Efhd1^em1Wei
• Allele Name: endonuclease-mediated mutation 1, Weizmann Institute of Science
• Allele ID: MGI:6711681
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Efhd1^em1Wei/Efhd1^em1Wei	Not Specified	MGI:6711689

Genotype
MGI:6711689

hm1

• Allelic Composition: Efhd1^em1Wei/Efhd1^em1Wei
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased neuron apoptosis ( J:305107 )

• at E17.5, but not E15.5, in the dorsal root ganglia

abnormal axon extension ( J:305107 )

• dorsal root ganglia explants from E13.5 embryos exhibit reduced axonal growth in vitro compared with wild-type cells

abnormal axon morphology ( J:305107 )

• dorsal root ganglia explants from E13.5 embryos exhibit short axons compared with wild-type cells

• E13.5 embryos exhibit reduced axonal coverage and decreased number of branches with reduced ATP levels and shortened mitochondria compared with wild-type cells

decreased neuron number ( J:305107 )

• at E17.5, but not E15.5, in the dorsal root ganglia

abnormal sensory neuron physiology ( J:305107 )

• mitochondrial dysfunction in sensory neurons

cellular

increased neuron apoptosis ( J:305107 )

• at E17.5, but not E15.5, in the dorsal root ganglia

abnormal axon extension ( J:305107 )

• dorsal root ganglia explants from E13.5 embryos exhibit reduced axonal growth in vitro compared with wild-type cells