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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		St8sia3em2Yich
endonuclease-mediated mutation 2, Yijuang Chern
MGI:6711694
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		St8sia3em2Yich/St8sia3em2Yich C57BL/6JNarl-St8sia3em2Yich MGI:6711807


Genotype
MGI:6711807
hm1
Allelic
Composition		 St8sia3em2Yich/St8sia3em2Yich
Genetic
Background		 C57BL/6JNarl-St8sia3em2Yich
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
St8sia3em2Yich mutation (0 available); any St8sia3 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal locomotor behavior ( J:285485 )
• less sensitive to increased motor activity effect of Adora2a (adenosine A2a receptor) antagonist SCH 58261
• more sensitive to reduced motor activity effect of (Drd2 (dopamine receptor D2) antagonist L-741626
• normal spontaneous locomotor behavior

homeostasis/metabolism
abnormal peptide metabolism ( J:285485 )
• reduced sialylation of N- and O-glycans in striatum




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory