Phenotypes associated with this allele

• Allele Symbol: Ak2^em1.1Dze
• Allele Name: endonuclease-mediated mutation 1.1, Petras Dzeja
• Allele ID: MGI:6711698
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	A1cf^Tg(Myh6-cre/Esr1*)1Jmk/A1cf^+ Ak2^em1.1Dze/Ak2^em1.1Dze	involves: 129 * C57BL/6 * FVB/N	MGI:6711700

Genotype
MGI:6711700

cn1

• Allelic Composition: A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺; Ak2^em1.1Dze/Ak2^em1.1Dze
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

dilated heart ventricle ( J:305579 )

• mice treated with tamoxifen at 6-8 weeks of age exhibit ventricular dilation, measured as an increase in end-diastolic and end-systolic volume, within 1-week post-induction

• cardiac chamber enlargement is transitory and recovers to pre-induction levels within 2 months

decreased heart left ventricle muscle contractility ( J:305579 )

• tamoxifen treated mice show a decrease in left ventricular ejection fraction within 1-week post-induction

• the reduced pump function is transitory and recovers to pre-induction levels within 2 months

abnormal heart echocardiography feature ( J:305579 )

• echocardiography shows an increase in end-diastolic and end-systolic volume and decreased left ventricular ejection fraction within 1-week post-tamoxifen induction

homeostasis/metabolism

abnormal metabolism ( J:305579 )

• tamoxifen-treated mice show increased fumarate and malate and the glycolytic metabolite glucose-6-phosophate in the myocardium

muscle

decreased heart left ventricle muscle contractility ( J:305579 )

• tamoxifen treated mice show a decrease in left ventricular ejection fraction within 1-week post-induction

• the reduced pump function is transitory and recovers to pre-induction levels within 2 months