Analysis Tools
cardiovascular system
|
• cardiomyocytes from sedentary mice exhibit focally disrupted intercalated disks and mildly widened cell-cell contacts compared with wild-type mice
• following chronic exercise, mice exhibit diffusely disturbed sarcomere archeology with substantially lower density of crosslinked F-actin fibers and smeared Z-I-A-M bands as well as disrupted intercalated disks, loss of cell-cell contacts, damaged mitochondria forming large necrotic clusters and lysosomal inclusions compare with wild-type mice
|
|
• in exercised mice
|
|
• in exercised mice
|
|
• mild in exercised mice
|
|
• impaired left ventricle relaxation with aging
|
|
• in 24 week old mice with increase in E/A ratio of mitral valve movement due to decreased A-wave amplitude in the left atrium size and abnormal interventricular septum longitudinal strain rate
• however, systolic function is normal
|
|
• premature ventricular contractions and bradycardia in exercised mice
|
|
• exercised mice exhibit an increase in end-diastolic left ventricle volume, increased left ventricle mass, thickened interventricular septum at end-systole and end-diastole, increased heart weight, increased cardiomyocyte surface area, premature ventricular contractions, and bradycardia compared with wild-type mice
• following chronic exercise, mice exhibit diffusely disturbed sarcomere archeology compare with wild-type mice
• however, exercised mice do not exhibit fibrosis or infiltration in the heart
|
behavior/neurological
|
• during acute stress running on a treadmill, 12-week old mice run shorter distances and shorter time before reaching exhaustion compared with wild-type mice
|
growth/size/body
|
• mild in exercised mice
|
homeostasis/metabolism
|
• during acute stress running on a treadmill, 12-week old mice run shorter distances and shorter time before reaching exhaustion compared with wild-type mice
|
|
• exercised mice exhibit an increase in end-diastolic left ventricle volume, increased left ventricle mass, thickened interventricular septum at end-systole and end-diastole, increased heart weight, increased cardiomyocyte surface area, premature ventricular contractions, and bradycardia compared with wild-type mice
• following chronic exercise, mice exhibit diffusely disturbed sarcomere archeology compare with wild-type mice
• however, exercised mice do not exhibit fibrosis or infiltration in the heart
|
muscle
|
• cardiomyocytes from sedentary mice exhibit focally disrupted intercalated disks and mildly widened cell-cell contacts compared with wild-type mice
• following chronic exercise, mice exhibit diffusely disturbed sarcomere archeology with substantially lower density of crosslinked F-actin fibers and smeared Z-I-A-M bands as well as disrupted intercalated disks, loss of cell-cell contacts, damaged mitochondria forming large necrotic clusters and lysosomal inclusions compare with wild-type mice
|
|
• in exercised mice
|
|
• impaired left ventricle relaxation with aging
|
|
• cardiomyocytes from sedentary mice exhibit focally disrupted intercalated disks and mildly widened cell-cell contacts compared with wild-type mice
• following chronic exercise, mice exhibit diffusely disturbed sarcomere archeology with substantially lower density of crosslinked F-actin fibers and smeared Z-I-A-M bands as well as disrupted intercalated disks, loss of cell-cell contacts, damaged mitochondria forming large necrotic clusters and lysosomal inclusions compare with wild-type mice
|
