Phenotypes associated with this allele

• Allele Symbol: Arhgef3^em1Chej
• Allele Name: endonuclease-mediated mutation 1, Jie Chen
• Allele ID: MGI:6712019
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arhgef3^em1Chej/Arhgef3^em1Chej	involves: C57BL/6N	MGI:6712185

Genotype
MGI:6712185

hm1

• Allelic Composition: Arhgef3^em1Chej/Arhgef3^em1Chej
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

muscle phenotype ( J:304135 )

N • under standard conditions do not show any abnormalities in muscle mass, force, fatigability, or injury susceptibility

abnormal muscle contractility ( J:304135 )

• unlike wild-type controls, mice do not display an age related decrease in specific muscle force

enhanced muscle regeneration ( J:304135 )

• following injury with BaCl2 increase in muscle mass is enhanced compared to similarly treated wild-type controls

• regenerated muscle fibers are larger than in similarly treated wild-type controls

• total muscle force increase after injury is increased compared to similarly treated wild-type controls

• recovery of muscle mass and force is faster in females compared to males

• inhibition of autophagy by chloroquine abolishes the enhanced muscle regeneration

• enhanced regeneration is seen at 3 and 10 months of age with a more prominent effect on muscle force in older mice indicating a reduction in age-related loss of muscle regeneration