Phenotypes associated with this allele

• Allele Symbol: Angptl7^em1Pli
• Allele Name: endonuclease-mediated mutation 1, Peng Li
• Allele ID: MGI:6712191
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Angptl7^em1Pli/Angptl7^em1Pli	Not Specified	MGI:6712192

Genotype
MGI:6712192

hm1

• Allelic Composition: Angptl7^em1Pli/Angptl7^em1Pli
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased granulocyte monocyte progenitor cell number ( J:301766 )

• fewer granulocyte/monocyte progenitors but similar numbers of erythroid precursors compared to wild-type controls

decreased hematopoietic stem cell number ( J:301766 )

• decrease in the number and percentage of LSK cells in the bone marrow of adults

• fewer long-term hematopoietic stem cells (Lin- Sca-1+ Kit+ Flk2- CD34-) in the bone marrow of adults

• when homozygous mutant mice are engrafted with wild-type bone marrow cells, fewer long-term hematopoietic stem cells are found in the reconstituted bone marrow indicating a non-cell autonomous phenotype

• when wild-type mice are engrafted with bone marrow cells from homozygous mutant mice no decrease in long-term hematopoietic stem cell numbers is seen

abnormal fetal liver hematopoietic progenitor cell morphology ( J:301766 )

• decrease in the number and percentage of Lin- Mac-1+ CD4- stem cells in the fetal liver