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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ikbipem1Bcgen
endonuclease-mediated mutation 1, Biocytogen LLC
MGI:6712194
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ikbipem1Bcgen/Ikbipem1Bcgen
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd MGI:6712195


Genotype
MGI:6712195
cn1
Allelic
Composition		 Ikbipem1Bcgen/Ikbipem1Bcgen
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbipem1Bcgen mutation (0 available); any Ikbip mutation (19 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to bacterial infection induced morbidity/mortality ( J:282971 )
• increase in mortality after injection with high dose LPS (30 mg/kg)

immune system
increased susceptibility to induced colitis ( J:282971 )
• increased weight loss, higher colitis scores, and shorter colonic lengths following DSS induced colitis
decreased macrophage cytokine production ( J:282971 )
• primary peritoneal macrophages show higher TNF-alpha and IL6 expression and secretion following stimulation with LPS, PGN, or poly(I:C)
increased circulating interleukin-6 level ( J:282971 )
• 4h after LPS stimulation
lung inflammation ( J:282971 )
• increase in infiltration of immune cells and more severe injuries after LPS treatment
increased susceptibility to bacterial infection induced morbidity/mortality ( J:282971 )
• increase in mortality after injection with high dose LPS (30 mg/kg)

digestive/alimentary system
increased susceptibility to induced colitis ( J:282971 )
• increased weight loss, higher colitis scores, and shorter colonic lengths following DSS induced colitis

homeostasis/metabolism
increased circulating interleukin-6 level ( J:282971 )
• 4h after LPS stimulation

hematopoietic system
decreased macrophage cytokine production ( J:282971 )
• primary peritoneal macrophages show higher TNF-alpha and IL6 expression and secretion following stimulation with LPS, PGN, or poly(I:C)

respiratory system
lung inflammation ( J:282971 )
• increase in infiltration of immune cells and more severe injuries after LPS treatment




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory