immune system
N |
• the increase in IL-22 secretion seen in in vitro polarized TH22 cells in single conditional Riok2 heterozygotes is blunted
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Allele Symbol Allele Name Allele ID |
Riok2tm1c(KOMP)Wtsi targeted mutation 1c, Wellcome Trust Sanger Institute MGI:6712634 |
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Summary |
7 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• the increase in IL-22 secretion seen in in vitro polarized TH22 cells in single conditional Riok2 heterozygotes is blunted
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• tamoxifen-induced mice exhibit reduced peripheral blood red blood cell numbers
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• tamoxifen-induced mice exhibit reduced hematocrit
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• tamoxifen-induced mice exhibit reduced hemoglobin
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice show an increase in RII and RIV erythroid precursors compared to IL-22-sufficient Riok2-haploinsufficent mice on day 7 after treatments with phenylhydrazine
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• mice exhibit increased numbers of peripheral blood red blood cells compared to IL-22-sufficient Riok2-haploinsufficent mice on day 7 after treatments with phenylhydrazine to induce acute hemolytic stress
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• mice show alleviation of the stress-induced (via phenylhydrazine treatment) anemia seen in IL-22-sufficient Riok2-haploinsufficent mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice show an improvement in peripheral blood red blood cell numbers and hematocrit levels, and an increase in RIII and RIV erythroid precursors in the bone marrow compared to Il22ra1-sufficient Riok2-haploinsufficent mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• 8-12 week of mice exposed to acute hemolytic stress induced by phenylhydrazine treatment succumb faster to a lethal dose of phenylhydrazine than controls
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• mice exhibit impaired erythropoiesis in the bone marrow
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• mice over 60 weeks of age exhibit anemia
• 8-12 week of mice exposed to acute hemolytic stress (induced by nonlethal phenylhydrazine treatment) develop more severe anemia and have a delayed red blood cell recovery response compared to controls and succumb faster to a lethal dose of phenylhydrazine
• wild-type mice transplanted with mutant whole bone marrow develop anemia
• treatment of mice with a neutralizing IL-22 antibody reverses phenylhydrazine-induced anemia
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• the percentage of proliferating granulocyte-macrophage progenitors in the bone marrow is increased
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• anemia in young phenylhydrazine-administered mice seen on day 7 is preceded by a reduction in bone marrow RIII and RIV erythroid precursor frequency on day 6, indicating an erythroid differentiation defect
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• aged mice exhibit reduced peripheral blood red blood cell numbers
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• in aged mice
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• in aged mice
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• mice exhibit a decreased percentage of neutrophils (neutropenia)
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• aged mice show increased numbers of natural killer T cells
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• mice exhibit an increased percentage of monocytes (monocytosis)
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• LSK (lineage-Sca-1+Kit+) cells from the bone marrow supplemented with growth factors give rise to an increased percentage of CD11b+ myeloid cells, indicating a cell-intrinsic myeloproliferative effect
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• frequency and numbers of early hematopoietic progenitors are normal in young mice, however long-term hematopoietic stem cells (LT-HSCs) are increased in the bone marrow of aged mice
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• aged mice show increased numbers of splenic IL-22+CD4+T cells
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• mice exhibit an increase in apoptosis of erythroid precursors
• erythroid precursors show a decrease in cell quiescence with cell cycle block at the G1 phase
• treatment of mice with a neutralizing IL-22 antibody reduces the frequency of apoptotic erythroid precursors
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• TH22 cells secrete elevated concentrations of IL-22
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• bone marrow cells show reduced nascent protein synthesis in vivo
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• the concentration of IL-22 in the serum and bone marrow fluid of aged mice is higher than in controls
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• 8-12 week of mice exposed to acute hemolytic stress induced by phenylhydrazine treatment succumb faster to a lethal dose of phenylhydrazine than controls
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• 8-12 week of mice exposed to acute hemolytic stress induced by nonlethal phenylhydrazine treatment develop more severe anemia and have a delayed red blood cell recovery response compared to controls
• treatment of mice with a neutralizing IL-22 antibody reverses phenylhydrazine-induced anemia
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• TH22 cells secrete elevated concentrations of IL-22
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• the concentration of IL-22 in the serum and bone marrow fluid of aged mice is higher than in controls
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• aged mice show increased numbers of innate lymphoid cells
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• mice exhibit a decreased percentage of neutrophils (neutropenia)
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• aged mice show increased numbers of natural killer T cells
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• mice exhibit an increased percentage of monocytes (monocytosis)
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• aged mice show increased numbers of splenic IL-22+CD4+T cells
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• naive T cells polarized toward the TH22 cell lineage show an increase in IL-22 secretion
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• no homozygous mice are recovered
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• peripheral blood red blood cell numbers are mildly reduced
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• hematocrit levels are mildly reduced
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• hemoglobin levels are mildly reduced
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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