Phenotypes associated with this allele

• Allele Symbol: Usp20^em1Dalin
• Allele Name: endonuclease-mediated mutation 1, Dandan Lin
• Allele ID: MGI:6713512
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp20^em1Dalin/Usp20^em1Dalin	involves: C57BL/6	MGI:6713513

Genotype
MGI:6713513

hm1

• Allelic Composition: Usp20^em1Dalin/Usp20^em1Dalin
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:274572 )

• mice infected with a lethal dose of HSV-1 begin to die at 3 days post infection (dpi) and all die by 6 dpi compared to wild-type mice which still show 25% survival around 7 dpi

immune system

abnormal circulating chemokine level ( J:274572 )

• mice infected with HSV-1 show decreased induction of CCL5 in the sera

decreased circulating interferon-beta level ( J:274572 )

• mice infected with HSV-1 show decreased induction of IFN-beta in the sera

decreased circulating interleukin-6 level ( J:274572 )

• mice infected with HSV-1 show decreased induction of IL-6 in the sera

decreased interferon-beta secretion ( J:274572 )

• bone marrow-derived dendritic cells and bone-marrow-derived macrophages infected with HSV-1 exhibit decreased production of IFN-beta

decreased tumor necrosis factor secretion ( J:274572 )

• bone marrow-derived dendritic cells and bone-marrow-derived macrophages infected with HSV-1 exhibit decreased production of TNF

increased susceptibility to Herpesvirales infection ( J:274572 )

• mice exhibit increased susceptibility to lethal HSV-1 infection, with exacerbated replication of the virus and titers in lungs and brains at 24 hours or 4 days after infection, respectively

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:274572 )

• mice infected with a lethal dose of HSV-1 begin to die at 3 days post infection (dpi) and all die by 6 dpi compared to wild-type mice which still show 25% survival around 7 dpi

homeostasis/metabolism

abnormal circulating chemokine level ( J:274572 )

• mice infected with HSV-1 show decreased induction of CCL5 in the sera

decreased circulating interferon-beta level ( J:274572 )

• mice infected with HSV-1 show decreased induction of IFN-beta in the sera

decreased circulating interleukin-6 level ( J:274572 )

• mice infected with HSV-1 show decreased induction of IL-6 in the sera