Phenotypes associated with this allele

• Allele Symbol: Zfp639^tm1.2Jaty
• Allele Name: targeted mutation 1.2, John AT Young
• Allele ID: MGI:6713584
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp639^tm1.2Jaty/Zfp639^tm1.2Jaty	involves: 129 * BALB/cJ * C57BL/6 * SJL	MGI:6714007

Genotype
MGI:6714007

hm1

• Allelic Composition: Zfp639^tm1.2Jaty/Zfp639^tm1.2Jaty
• Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:305874 )

N • normal B and T lymphocyte levels in spleen and thymus

N • normal hematopoietic stem cell (HSC) and multipotent progenitor (MPP) populations in bone marrow

decreased susceptibility to Retroviridae infection ( J:305874 )

• reduced virus titers in bone marrow 10 days after inoculation with Mo-MuLV at age P2-P3

• 4.2-6.5x reduced virus replication in bone marrow 10 days after inoculation with Mo-MuLV at age P2-P3

• 3.9x reduced virus replication in T cells, 4.1x in B cells and 6.6x in non-B/-T cells from bone marrow 10 days after inoculation with Moloney murine leukemia virus (Mo-MuLV) at age P2-P3

hematopoietic system

increased common myeloid progenitor cell number ( J:305874 )

• 1.5x increase in lin- ska- kit+ (LK) population in bone marrow

mortality/aging

mortality/aging ( J:305874 )

N • normal lifespan

behavior/neurological

behavior/neurological phenotype ( J:305874 )

N • no obvious behavioral phenotype

embryo

embryo phenotype ( J:305874 )

N • mice born at normal Mendelian ratio

growth/size/body

growth/size/body region phenotype ( J:305874 )

N • normal weight, no obvious phenotype

neoplasm

neoplasm ( J:305874 )

N • normal tumor incidence up to 1 year after inoculation with Moloney murine leukemia virus (Mo-MuLV) at age P2-P3