Analysis Tools
behavior/neurological
| N |
• normal locomotor behavior in open field test
• normal behavior in Y-maze and cued/contextual fear conditioning tests
• normal level of submission/dominance in tube social dominance test
|
|
• preference to stay in the dark and to make fewer visits between light and dark areas in light/dark box test
• more time spent in closed area and fewer entries into the open area in elevated zero-maze
|
|
• less time spent with novel mouse in three-chamber test
• normal distance traveled, normal time spent with novel object and normal frequency in visits to different chambers in three-chamber test
|
cellular
|
• reduced number of LysoTracker-positive organelles and reduced fluorescence of positive organelles in cortical neurons
• reduction in number LAMP1-positive puncta and reduced overall LAMP1-positive signal in cortical neurons
|
|
• reduced number of LysoTracker-positive organelles and reduced fluorescence of positive organelles in cortical neurons
• increased pH in cortical neurons
• reduction in number LAMP1-positive puncta and reduced overall LAMP1-positive signal in cortical neurons
• significant reduction in processing of exogenous DQ-BSA and Dextran-AF594 in cortical neurons
• increased accumulation of cytosolic granules in in cortical neurons
|
homeostasis/metabolism
nervous system
| N |
• no overt brain morphology anomalies; no cell death in brain at up to age 18 months
• normal number of inhibitory contacts on cortical and somatosensory cortex neurons
|
|
• more proximal neurites on cortical neuron neuronal processes
• reduced number of calbindin (CB)-positive interneurons in somatosensory and visual cortex
• normal cortical neuron neuronal process length on cortical neurons
|
|
• reduction of inhibitory contacts on cortical and somatosensory cortex neurons
|
renal/urinary system
