Phenotypes associated with this allele

• Allele Symbol: Ccdc6^tm1Afus
• Allele Name: targeted mutation 1, Alfredo Fusco
• Allele ID: MGI:6714085
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccdc6^tm1Afus/Ccdc6^tm1Afus	involves: 129 * C57BL/6J	MGI:6714086

Genotype
MGI:6714086

hm1

• Allelic Composition: Ccdc6^tm1Afus/Ccdc6^tm1Afus
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:301625 )

• fewer than the expected numbers of homozygotes are obtained, indicating embryonic lethality

endocrine/exocrine glands

thyroid gland hyperplasia ( J:301625 )

• 15 of 30 mice develop thyroid hyperplasia at 17-22 months of age; atypical follicles contain eosinophilic secretory and inactive material

homeostasis/metabolism

increased thyroxine level ( J:301625 )

• 13-month-old mice exhibit high T4 levels

increased triiodothyronine level ( J:301625 )

• 13-month-old mice exhibit high T3 levels

decreased thyroid-stimulating hormone level ( J:301625 )

• 13-month-old mice exhibit low TSH levels

cellular

abnormal cell cycle ( J:301625 )

• MEFs accumulate in the G2 phase of the cell cycle and the percentage of MEFs in the G1 and S phase are reduced compared to wild-type MEFs

increased cellular sensitivity to hydrogen peroxide ( J:301625 )

• MEFs show increased sensitivity to high doses of hydrogen peroxide

increased fibroblast apoptosis ( J:301625 )

• MEFs exhibit increased susceptibility to apoptosis

decreased fibroblast proliferation ( J:301625 )

• mouse embryonic fibroblasts (MEFs) from E12.5 embryos show a slower proliferation rate