Phenotypes associated with this allele

• Allele Symbol: Plet1^tm1Cupe
• Allele Name: targeted mutation 1, Tom Cupedo
• Allele ID: MGI:6714310
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plet1^tm1Cupe/Plet1^tm1Cupe	Not Specified	MGI:6714318

Genotype
MGI:6714318

hm1

• Allelic Composition: Plet1^tm1Cupe/Plet1^tm1Cupe
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal dendritic cell migration ( J:271548 )

• bone marrow-derived dendritic cells and total small intestine lamina propria dendritic cells show a defect in migrating through a 3D collagen I matrix, with only half of the cells egressing from the matrix

digestive/alimentary system

abnormal small intestinal villus morphology ( J:271548 )

• increase in CD103+CD3- cells within the lower parts of the illeal villi

• however, mice show normal small intestine at 8-12 weeks of age, show normal intestinal system development

hematopoietic system

abnormal dendritic cell migration ( J:271548 )

• bone marrow-derived dendritic cells and total small intestine lamina propria dendritic cells show a defect in migrating through a 3D collagen I matrix, with only half of the cells egressing from the matrix

abnormal dendritic cell number ( J:271548 )

• chimeric mice containing mutant bone marrow show an increased frequency of total dendritic cells in the small intestine lamina propria that is concomitant with a diminished proportion of total dendritic cells in the mesenteric lymph nodes

increased dendritic cell number ( J:271548 )

• increase in the percentage of total intestinal dendritic cells and this increase is mainly due to an accumulation of CD11b+CD103+ dendritic cells

• however, frequencies of dendritic cells in the mesenteric lymph nodes are comparable to wild-type levels

immune system

abnormal dendritic cell migration ( J:271548 )

• bone marrow-derived dendritic cells and total small intestine lamina propria dendritic cells show a defect in migrating through a 3D collagen I matrix, with only half of the cells egressing from the matrix

abnormal dendritic cell number ( J:271548 )

• chimeric mice containing mutant bone marrow show an increased frequency of total dendritic cells in the small intestine lamina propria that is concomitant with a diminished proportion of total dendritic cells in the mesenteric lymph nodes

increased dendritic cell number ( J:271548 )

• increase in the percentage of total intestinal dendritic cells and this increase is mainly due to an accumulation of CD11b+CD103+ dendritic cells

• however, frequencies of dendritic cells in the mesenteric lymph nodes are comparable to wild-type levels